phosphoenolpyruvate carboxykinase

URI: https://gptkb.org/entity/phosphoenolpyruvate_carboxykinase
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName PEPCK
phosphopyruvate carboxykinase
GTP:oxaloacetate carboxy-lyase (transphosphorylating)
gptkbp:catalyzes conversion of oxaloacetate to phosphoenolpyruvate
gptkbp:cofactor gptkb:ATP
gptkb:GTP
gptkbp:EC_number 4.1.1.32
gptkbp:expressedIn gptkb:kidney
gptkb:small_intestine
liver
adipose tissue
gptkbp:foundIn mitochondria
cytosol
gptkbp:gene PCK1
PCK2
gptkbp:GO_term GO:0004611
https://www.w3.org/2000/01/rdf-schema#label phosphoenolpyruvate carboxykinase
gptkbp:inhibitedBy 3-mercaptopicolinic acid
gptkbp:involves gluconeogenesis
gptkbp:KEGGID K01610
gptkbp:locatedOnChromosome 14q11.2 (PCK2, human)
20q13.31 (PCK1, human)
gptkbp:molecularWeight ~62 kDa (human, cytosolic)
~69 kDa (human, mitochondrial)
gptkbp:OMIM 172400 (PCK1)
601656 (PCK2)
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Bacteria
gptkbp:pathway gluconeogenesis
glyceroneogenesis
gptkbp:PDB 1KHE
1KHG
gptkbp:product gptkb:ADP
gptkb:GDP
CO2
phosphoenolpyruvate
gptkbp:Reactome gptkb:R-HSA-70263
gptkbp:regulates gptkb:glucagon
gptkb:cAMP
gptkb:insulin
cortisol
gptkbp:significance gptkb:diabetes_mellitus
fasting adaptation
gptkbp:structure monomer
gptkbp:substrate gptkb:oxaloacetate
gptkbp:UniProtID P35558 (human, cytosolic)
Q16822 (human, mitochondrial)
gptkbp:bfsParent gptkb:oxaloacetate
gptkbp:bfsLayer 6