Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
hyperphenylalaninemia
|
| gptkbp:catalyzes |
conversion of phenylalanine to tyrosine
|
| gptkbp:cofactor |
gptkb:tetrahydrobiopterin
iron molecular oxygen |
| gptkbp:deficiencyCauses |
gptkb:phenylketonuria
|
| gptkbp:EC_number |
1.14.16.1
|
| gptkbp:encodedBy |
PAH gene
|
| gptkbp:foundIn |
gptkb:kidney
liver |
| gptkbp:locatedIn |
cytosol
|
| gptkbp:molecularWeight |
~50 kDa (monomer)
|
| gptkbp:OMIM |
612349
|
| gptkbp:product |
gptkb:L-tyrosine
|
| gptkbp:regulates |
phosphorylation
allosteric activation by phenylalanine |
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
gptkb:L-phenylalanine
|
| gptkbp:UniProtID |
P00439
|
| gptkbp:bfsParent |
gptkb:phenylketonuria
gptkb:NM_000402 gptkb:CHEBI:16414 gptkb:Phenylalanine |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
phenylalanine hydroxylase
|