Statements (23)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:enzyme
|
gptkbp:associatedWith |
hyperphenylalaninemia
|
gptkbp:catalyzes |
conversion of phenylalanine to tyrosine
|
gptkbp:cofactor |
gptkb:tetrahydrobiopterin
iron molecular oxygen |
gptkbp:deficiencyCauses |
gptkb:phenylketonuria
|
gptkbp:EC_number |
1.14.16.1
|
gptkbp:encodedBy |
PAH gene
|
gptkbp:foundIn |
gptkb:kidney
liver |
https://www.w3.org/2000/01/rdf-schema#label |
phenylalanine hydroxylase
|
gptkbp:locatedIn |
cytosol
|
gptkbp:molecularWeight |
~50 kDa (monomer)
|
gptkbp:OMIM |
612349
|
gptkbp:product |
gptkb:L-tyrosine
|
gptkbp:regulates |
phosphorylation
allosteric activation by phenylalanine |
gptkbp:structure |
homotetramer
|
gptkbp:substrate |
gptkb:L-phenylalanine
|
gptkbp:UniProtID |
P00439
|
gptkbp:bfsParent |
gptkb:Phenylalanine
|
gptkbp:bfsLayer |
6
|