Statements (74)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
3
|
| gptkbp:bfsParent |
gptkb:healthcare_organization
|
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:non-Hodgkin_lymphoma gptkb:cervical_cancer gptkb:Li-Fraumeni_syndrome gptkb:Wilms_tumor gptkb:head_and_neck_cancers gptkb:neuroblastoma gptkb:biliary_tract_cancer ovarian cancer liver cancer stomach cancer oral cancer esophageal cancer small cell lung cancer bladder cancer neuroendocrine tumors thymoma cholangiosarcoma sarcomas germ cell tumors large cell lung cancer adrenocortical carcinoma squamous cell carcinoma of the lung adenocarcinoma of the lung anaplastic thyroid carcinoma cervical intraepithelial neoplasia. |
| gptkbp:clinical_trial |
biomarker for cancer prognosis
|
| gptkbp:consequences |
tumorigenesis
|
| gptkbp:ecological_role |
regulates cell cycle progression
|
| gptkbp:established |
cell proliferation
angiogenesis DNA repair genes cell cycle progression in G1 phase senescence pathways |
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_diversity |
loss of function
missense mutations high in various cancers |
| https://www.w3.org/2000/01/rdf-schema#label |
p53 gene
|
| gptkbp:influences |
immune response
cellular aging stem cell fate |
| gptkbp:interacts_with |
gptkb:ATM_protein
gptkb:ATR_protein MD M2 protein CBP protein CH K2 protein p300 protein |
| gptkbp:is_involved_in |
DNA damage response
cellular stress response cellular differentiation metastasis apoptotic signaling pathways |
| gptkbp:is_studied_in |
clinical trials
gene therapy approaches |
| gptkbp:is_vulnerable_to |
activates DNA repair mechanisms
|
| gptkbp:known_for |
guardian of the genome
|
| gptkbp:location |
gptkb:physicist
|
| gptkbp:nutritional_value |
tetrameric form
|
| gptkbp:promoter |
regulates gene expression
T P53 |
| gptkbp:promotes |
apoptosis
|
| gptkbp:regulates |
metabolism
|
| gptkbp:regulatory_compliance |
post-translational modifications
|
| gptkbp:research_focus |
cancer biology
|
| gptkbp:seed_dispersal |
17p13.1
|
| gptkbp:social_responsibility |
gptkb:healthcare_organization
|
| gptkbp:targets |
gptkb:healthcare_organization
p21, Bax, and others |
| gptkbp:transcribed_for |
p53 protein
|
| gptkbp:year_created |
gptkb:1979
|