|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
gptkb:NADH:ubiquinone_oxidoreductase
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
mitochondrial diseases
|
|
gptkbp:compatibleWith
|
some anaerobic organisms
|
|
gptkbp:component
|
electron transport chain
|
|
gptkbp:composedOf
|
multiple protein subunits
|
|
gptkbp:contains
|
gptkb:FMN
iron-sulfur clusters
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:EC_number
|
1.6.5.3
|
|
gptkbp:encodedBy
|
gptkb:mitochondrial_DNA
nuclear DNA
|
|
gptkbp:function
|
pumps protons across mitochondrial membrane
catalyzes electron transfer from NADH to ubiquinone
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mitochondrial complex I
|
|
gptkbp:inhibitedBy
|
gptkb:piericidin_A
gptkb:rotenone
amytal
|
|
gptkbp:locatedIn
|
inner mitochondrial membrane
|
|
gptkbp:molecularWeight
|
~1 MDa (megadalton)
|
|
gptkbp:mutationAssociatedWith
|
causes Leber's hereditary optic neuropathy
causes Leigh syndrome
|
|
gptkbp:orthologIn
|
bacterial NDH-1 complex
|
|
gptkbp:presentIn
|
eukaryotes
|
|
gptkbp:product
|
gptkb:ubiquinol
NAD+
proton gradient
|
|
gptkbp:requires
|
oxidative phosphorylation
|
|
gptkbp:role
|
ATP synthesis
|
|
gptkbp:structure
|
L-shaped
|
|
gptkbp:studiedBy
|
cryo-electron microscopy
|
|
gptkbp:substrate
|
gptkb:NADH
ubiquinone
|
|
gptkbp:subunit
|
at least 45 subunits in mammals
|
|
gptkbp:bfsParent
|
gptkb:ND1
gptkb:NDUFS2
gptkb:NDUFS3
gptkb:NDUFS4
gptkb:NDUFS7
gptkb:NDUFS8
gptkb:NDUFV2
gptkb:NDUFV3
|
|
gptkbp:bfsLayer
|
7
|