|
gptkbp:instanceOf
|
gptkb:drug
synthetic steroid
|
|
gptkbp:approvedBy
|
gptkb:France
gptkb:United_Kingdom
gptkb:United_States
1988
|
|
gptkbp:ATCCode
|
G03XB01
|
|
gptkbp:brand
|
gptkb:Korlym
Mifeprex
|
|
gptkbp:CASNumber
|
gptkb:84371-65-3
|
|
gptkbp:chemicalFormula
|
gptkb:C29H35NO2
|
|
gptkbp:combines
|
gptkb:misoprostol
|
|
gptkbp:contraindication
|
anticoagulant therapy
ectopic pregnancy
chronic adrenal failure
hemorrhagic disorders
|
|
gptkbp:developedBy
|
Roussel Uclaf
|
|
gptkbp:discoveredBy
|
1980
|
|
gptkbp:drugClass
|
antiprogestogen
abortifacient
corticosteroid receptor antagonist
|
|
gptkbp:eliminationHalfLife
|
18-25 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mifepristone
|
|
gptkbp:KEGGID
|
D00423
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:France
|
|
gptkbp:mechanismOfAction
|
progesterone receptor antagonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
429.6 g/mol
|
|
gptkbp:otherName
|
gptkb:RU-486
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
X
X (contraindicated in pregnancy except for abortion)
|
|
gptkbp:prescribes
|
hyperglycemia in Cushing's syndrome
termination of intrauterine pregnancy
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1423
49936
55245
DB00834
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
abdominal pain
fatigue
vaginal bleeding
|
|
gptkbp:UNII
|
320T6RNW1F
|
|
gptkbp:usedFor
|
gptkb:Cushing's_syndrome
medical abortion
management of miscarriage
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Progesterone_receptor
gptkb:Medical_Termination_of_Pregnancy
|
|
gptkbp:bfsLayer
|
7
|