|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:MDH
gptkb:malate_dehydrogenase
|
|
gptkbp:catalyzes
|
oxidation of malate to oxaloacetate
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Hans_Krebs
|
|
gptkbp:discoveredIn
|
1937
|
|
gptkbp:EC_number
|
1.1.1.37
|
|
gptkbp:enzymeClassification
|
oxidoreductase
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:gene
|
gptkb:MDH1
gptkb:MDH2
|
|
gptkbp:gene_location_(MDH1,_human)
|
chromosome 2
|
|
gptkbp:gene_location_(MDH2,_human)
|
gptkb:chromosome_7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
malic dehydrogenase
|
|
gptkbp:inhibitedBy
|
gptkb:oxaloacetate
high NADH/NAD+ ratio
|
|
gptkbp:involves
|
gptkb:malate-aspartate_shuttle
citric acid cycle
|
|
gptkbp:isozyme
|
cytosolic malic dehydrogenase
mitochondrial malic dehydrogenase
|
|
gptkbp:molecularWeight
|
~35 kDa (per subunit)
|
|
gptkbp:optimum_pH
|
7.5
|
|
gptkbp:organism
|
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Bacteria
|
|
gptkbp:pathway
|
amino acid metabolism
gluconeogenesis
|
|
gptkbp:PDB
|
gptkb:1MLD
gptkb:4MDH
|
|
gptkbp:product
|
gptkb:H+
gptkb:NADH
gptkb:oxaloacetate
|
|
gptkbp:regulates
|
allosteric regulation
substrate availability
|
|
gptkbp:significance
|
marker for myocardial infarction
marker for tissue damage
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
malate
NAD+
|
|
gptkbp:systematicName
|
gptkb:(S)-malate:NAD+_oxidoreductase
|
|
gptkbp:type
|
(S)-malate + NAD+ ⇌ oxaloacetate + NADH + H+
|
|
gptkbp:used_in
|
metabolic engineering
clinical diagnostics
biochemical assays
|
|
gptkbp:bfsParent
|
gptkb:malate_dehydrogenase
|
|
gptkbp:bfsLayer
|
6
|