|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
iron atom
|
|
gptkbp:alternativeName
|
gptkb:LOX
linoleate:oxygen oxidoreductase
|
|
gptkbp:catalyzes
|
dioxygenation of polyunsaturated fatty acids
|
|
gptkbp:EC_number
|
1.13.11.12
|
|
gptkbp:firstDescribed
|
1940s
|
|
gptkbp:foundIn
|
animals
fungi
plants
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lipoxygenase enzymes
|
|
gptkbp:inhibitedBy
|
gptkb:nordihydroguaiaretic_acid
zileuton
|
|
gptkbp:involvedIn
|
inflammatory response
lipid peroxidation
jasmonic acid biosynthesis
|
|
gptkbp:locatedOnChromosome
|
varies by species
|
|
gptkbp:molecularWeight
|
~75-100 kDa
|
|
gptkbp:presentIn
|
gptkb:wheat
garlic
soybeans
human leukocytes
|
|
gptkbp:produces
|
hydroperoxides
|
|
gptkbp:product
|
gptkb:leukotrienes
gptkb:lipoxins
hydroxyeicosatetraenoic acids
|
|
gptkbp:proteinFamily
|
LOX gene family
|
|
gptkbp:requireCofactor
|
iron
|
|
gptkbp:roleInAnimals
|
eicosanoid synthesis
inflammatory mediator production
|
|
gptkbp:roleInPlants
|
seed germination
defense response
flavor formation
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:cardiovascular_disease
asthma
inflammation
|
|
gptkbp:structure
|
non-heme iron-containing
|
|
gptkbp:subspecies
|
gptkb:15-lipoxygenase
12-lipoxygenase
5-lipoxygenase
13-lipoxygenase
9-lipoxygenase
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
gptkb:linoleic_acid
|
|
gptkbp:type
|
oxidation
oxygenation
|
|
gptkbp:bfsParent
|
gptkb:arachidonic_acid
|
|
gptkbp:bfsLayer
|
7
|