|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:15-LO
gptkb:15-LOX
gptkb:ALOX15
gptkb:arachidonate_15-lipoxygenase
leukocyte-type 15-lipoxygenase
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes
12-lipoxygenase
5-lipoxygenase
|
|
gptkbp:catalyzes
|
oxygenation of polyunsaturated fatty acids
|
|
gptkbp:cofactor
|
iron
|
|
gptkbp:discoveredBy
|
gptkb:E.J._Corey
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:EC_number
|
1.13.11.33
|
|
gptkbp:Entrez_Gene_ID
|
GC17M007774
|
|
gptkbp:expressedIn
|
macrophages
epithelial cells
reticulocytes
|
|
gptkbp:foundIn
|
humans
mice
rabbits
|
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gptkbp:gene
|
gptkb:ALOX15
|
|
gptkbp:GO_component
|
cytosol
|
|
gptkbp:GO_function
|
arachidonic acid 15-lipoxygenase activity
|
|
gptkbp:GOProcess
|
inflammatory response
lipid metabolic process
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
15-lipoxygenase
|
|
gptkbp:inhibitedBy
|
gptkb:baicalein
gptkb:nordihydroguaiaretic_acid_(NDGA)
zileuton
|
|
gptkbp:InterPro
|
IPR001246
|
|
gptkbp:involves
|
asthma
cell differentiation
atherosclerosis
inflammation
|
|
gptkbp:locatedOnChromosome
|
17p13.1
|
|
gptkbp:OMIM
|
603697
|
|
gptkbp:product
|
13-hydroperoxyoctadecadienoic acid (13-HPODE)
15-hydroperoxyeicosatetraenoic acid (15-HPETE)
|
|
gptkbp:proteinFamily
|
PF00305
|
|
gptkbp:structure
|
contains non-heme iron
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
gptkb:linoleic_acid
|
|
gptkbp:UniProtID
|
P16050
|
|
gptkbp:bfsParent
|
gptkb:ALOX15
gptkb:arachidonate_15-lipoxygenase
|
|
gptkbp:bfsLayer
|
7
|