Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alternativeName |
gptkb:mast_cell_growth_factor
multi-colony stimulating factor |
| gptkbp:category |
gptkb:protein
immune system molecule |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:encodedBy |
IL3 gene
|
| gptkbp:Entrez_Gene_ID |
3562
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
stimulates proliferation and differentiation of hematopoietic cells
supports growth of multipotent hematopoietic stem cells |
| gptkbp:HGNC_ID |
6016
|
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-3
|
| gptkbp:involvedIn |
immune response
allergic inflammation hematopoiesis |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5
5q31.1 |
| gptkbp:molecularWeight |
15-20 kDa
|
| gptkbp:OMIM |
147740
|
| gptkbp:partOf |
hematopoietic growth factors
interleukin family |
| gptkbp:PDB |
1JLI
|
| gptkbp:producedBy |
gptkb:mast_cells
activated T cells |
| gptkbp:promotion |
colony formation in bone marrow
|
| gptkbp:receptorComponent |
gptkb:IL3RA
CSF2RB |
| gptkbp:recipient |
heterodimeric
interleukin-3 receptor |
| gptkbp:regulates |
basophil production
dendritic cell production eosinophil production erythroid cell production granulocyte production induced by antigen stimulation macrophage production megakaryocyte production regulated by transcription factors |
| gptkbp:significance |
leukemia
autoimmune diseases allergic diseases |
| gptkbp:species |
gptkb:human
gptkb:mouse right |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:subunit |
single polypeptide chain
|
| gptkbp:symbol |
IL-3
|
| gptkbp:UniProtID |
P08700
|
| gptkbp:bfsParent |
gptkb:eosinophils
|
| gptkbp:bfsLayer |
7
|