Statements (40)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:alternativeName |
AGIF
IL-11 adipogenesis inhibitory factor |
| gptkbp:approvedDrugIndication |
thrombocytopenia
|
| gptkbp:associatedWith |
gptkb:cancer
rheumatoid arthritis fibrosis inflammatory bowel disease |
| gptkbp:category |
signaling molecule
cytokine hematopoietic growth factor |
| gptkbp:discoveredBy |
Paul S. Linsley
|
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodedBy |
IL11 gene
|
| gptkbp:Entrez_Gene_ID |
3590
|
| gptkbp:function |
bone metabolism
modulation of immune response hematopoiesis anti-inflammatory effects stimulates megakaryocyte maturation |
| gptkbp:hasRefSeqID |
NM_000641
|
| gptkbp:HGNC_ID |
HGNC:5967
|
| https://www.w3.org/2000/01/rdf-schema#label |
interleukin-11
|
| gptkbp:locatedOnChromosome |
19q13.3-q13.4
|
| gptkbp:molecularWeight |
19 kDa
|
| gptkbp:OMIM |
147681
|
| gptkbp:producedBy |
fibroblasts
stromal cells osteoblasts |
| gptkbp:recipient |
gptkb:gp130
interleukin-11 receptor alpha |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
four-helix bundle
|
| gptkbp:UniProtID |
P20809
|
| gptkbp:usedAsDrug |
oprelvekin
|
| gptkbp:bfsParent |
gptkb:gp130_receptor
|
| gptkbp:bfsLayer |
6
|