|
gptkbp:instanceOf
|
gptkb:cytokine
gptkb:protein
|
|
gptkbp:alternativeName
|
AGIF
IL-11
adipogenesis inhibitory factor
|
|
gptkbp:approvedDrugIndication
|
thrombocytopenia
|
|
gptkbp:associatedWith
|
gptkb:inflammatory_bowel_disease
gptkb:cancer
rheumatoid arthritis
fibrosis
|
|
gptkbp:category
|
gptkb:cytokine
gptkb:signaling_molecule
hematopoietic growth factor
|
|
gptkbp:discoveredBy
|
Paul S. Linsley
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
IL11 gene
|
|
gptkbp:Entrez_Gene_ID
|
3590
|
|
gptkbp:function
|
bone metabolism
modulation of immune response
hematopoiesis
anti-inflammatory effects
stimulates megakaryocyte maturation
|
|
gptkbp:hasRefSeqID
|
NM_000641
|
|
gptkbp:HGNC_ID
|
HGNC:5967
|
|
gptkbp:locatedOnChromosome
|
19q13.3-q13.4
|
|
gptkbp:molecularWeight
|
19 kDa
|
|
gptkbp:OMIM
|
147681
|
|
gptkbp:producedBy
|
fibroblasts
stromal cells
osteoblasts
|
|
gptkbp:recipient
|
gptkb:gp130
interleukin-11 receptor alpha
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:UniProtID
|
P20809
|
|
gptkbp:usedAsDrug
|
oprelvekin
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6_family
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-11
|