Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:monoclonal_antibody
|
| gptkbp:abbreviation |
gptkb:IgG
|
| gptkbp:binds |
gptkb:Fc_receptors
antigens |
| gptkbp:canActivate |
classical complement pathway
|
| gptkbp:contains |
two heavy chains
two light chains |
| gptkbp:crosses |
gptkb:placenta
|
| gptkbp:decreasedIn |
immunodeficiency
nephrotic syndrome |
| gptkbp:discoveredBy |
Elvin A. Kabat
|
| gptkbp:doesNotActivate |
alternative complement pathway
|
| gptkbp:domain |
Fab region
Fc region |
| gptkbp:elevatedIn |
autoimmune diseases
chronic infections |
| gptkbp:encodedBy |
gptkb:IGHG_gene_family
|
| gptkbp:firstDescribed |
1950s
|
| gptkbp:foundIn |
blood
extracellular fluid |
| gptkbp:function |
immune response
opsonization activation of complement system neutralization of pathogens |
| gptkbp:halfLife |
about 21 days
|
| gptkbp:hasAllotype |
Gm marker
|
| https://www.w3.org/2000/01/rdf-schema#label |
immunoglobulin G
|
| gptkbp:measures |
gptkb:ELISA
immunoturbidimetry nephelometry |
| gptkbp:molecularWeight |
150 kDa
|
| gptkbp:mostAbundantAntibodyIn |
human serum
|
| gptkbp:notableFor |
longest half-life among immunoglobulins
|
| gptkbp:percentageOfSerumAntibodies |
~75%
|
| gptkbp:presentIn |
all mammals
|
| gptkbp:producedBy |
plasma cells
|
| gptkbp:provides |
passive immunity to fetus
|
| gptkbp:role |
secondary immune response
|
| gptkbp:structure |
Y-shaped
|
| gptkbp:subclassOf |
gptkb:IgG2
gptkb:IgG3 gptkb:IgG1 gptkb:IgG4 immune response |
| gptkbp:target |
autoimmune diseases
|
| gptkbp:usedAs |
marker for past infection
therapeutic antibody |
| gptkbp:usedIn |
immunotherapy
diagnostic tests intravenous immunoglobulin therapy (IVIG) |
| gptkbp:bfsParent |
gptkb:Protein_A
gptkb:Gammagard |
| gptkbp:bfsLayer |
7
|