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gptkbp:instanceOf
|
gptkb:monoclonal_antibody
|
|
gptkbp:abbreviation
|
gptkb:IgG
|
|
gptkbp:binds
|
gptkb:Fc_receptors
antigens
|
|
gptkbp:canActivate
|
classical complement pathway
|
|
gptkbp:contains
|
two heavy chains
two light chains
|
|
gptkbp:crosses
|
gptkb:placenta
|
|
gptkbp:decreasedIn
|
gptkb:nephrotic_syndrome
gptkb:immunodeficiency
|
|
gptkbp:discoveredBy
|
Elvin A. Kabat
|
|
gptkbp:doesNotActivate
|
alternative complement pathway
|
|
gptkbp:domain
|
Fab region
Fc region
|
|
gptkbp:elevatedIn
|
autoimmune diseases
chronic infections
|
|
gptkbp:encodedBy
|
gptkb:IGHG_gene_family
|
|
gptkbp:firstDescribed
|
1950s
|
|
gptkbp:foundIn
|
blood
extracellular fluid
|
|
gptkbp:function
|
gptkb:immune_response
opsonization
activation of complement system
neutralization of pathogens
|
|
gptkbp:halfLife
|
about 21 days
|
|
gptkbp:hasAllotype
|
Gm marker
|
|
gptkbp:measures
|
gptkb:ELISA
immunoturbidimetry
nephelometry
|
|
gptkbp:molecularWeight
|
150 kDa
|
|
gptkbp:mostAbundantAntibodyIn
|
human serum
|
|
gptkbp:notableFor
|
longest half-life among immunoglobulins
|
|
gptkbp:percentageOfSerumAntibodies
|
~75%
|
|
gptkbp:presentIn
|
all mammals
|
|
gptkbp:producedBy
|
plasma cells
|
|
gptkbp:provides
|
passive immunity to fetus
|
|
gptkbp:role
|
secondary immune response
|
|
gptkbp:structure
|
Y-shaped
|
|
gptkbp:subclassOf
|
gptkb:IgG2
gptkb:IgG3
gptkb:immune_response
gptkb:IgG1
gptkb:IgG4
|
|
gptkbp:target
|
autoimmune diseases
|
|
gptkbp:usedAs
|
marker for past infection
therapeutic antibody
|
|
gptkbp:usedIn
|
gptkb:immunotherapy
diagnostic tests
intravenous immunoglobulin therapy (IVIG)
|
|
gptkbp:bfsParent
|
gptkb:Protein_A
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
immunoglobulin G
|