Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
heparanase endo-β-D-glucuronidase
heparanase-1 |
| gptkbp:associatedWith |
angiogenesis
inflammation tumor metastasis |
| gptkbp:discoveredBy |
1999
|
| gptkbp:EC_number |
3.2.1.166
|
| gptkbp:expressedIn |
gptkb:placenta
endothelial cells immune cells |
| gptkbp:function |
degrades heparan sulfate
endoglycosidase activity |
| gptkbp:gene |
HPSE
|
| https://www.w3.org/2000/01/rdf-schema#label |
heparanase
|
| gptkbp:inhibitedBy |
gptkb:heparin
PI-88 |
| gptkbp:locatedOnChromosome |
4q21.23
|
| gptkbp:location |
gptkb:lysosome
extracellular matrix |
| gptkbp:molecularWeight |
50 kDa
|
| gptkbp:role |
atherosclerosis
autoimmune diseases cancer progression diabetes complications inflammatory bowel disease |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
glycoside hydrolase family 79
|
| gptkbp:substrate |
gptkb:heparan_sulfate_proteoglycans
|
| gptkbp:UniProtID |
Q9Y251
|
| gptkbp:bfsParent |
gptkb:heparan_sulfate_proteoglycans
gptkb:Heparan_sulfate |
| gptkbp:bfsLayer |
7
|