fluorouracil

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antineoplastic agent
gptkbp:ATCCode L01BC02
gptkbp:brand gptkb:Carac
gptkb:Efudex
Adrucil
Fluoroplex
gptkbp:CASNumber 51-21-8
gptkbp:category World Health Organization essential medicine
DNA synthesis inhibitor
pyrimidine analog
gptkbp:chemicalFormula C4H3FN2O2
gptkbp:combines gptkb:leucovorin
gptkb:irinotecan
gptkb:oxaliplatin
gptkb:cisplatin
gptkbp:discoveredBy 1957
Charles Heidelberger
gptkbp:eliminationHalfLife 10-20 minutes
gptkbp:excretion urine
https://www.w3.org/2000/01/rdf-schema#label fluorouracil
gptkbp:IUPACName 5-fluoropyrimidine-2,4(1H,3H)-dione
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits thymidylate synthase
gptkbp:metabolism gptkb:dihydropyrimidine_dehydrogenase
gptkbp:molecularWeight 130.08 g/mol
gptkbp:pregnancyCategory D (US)
gptkbp:routeOfAdministration topical
intravenous
gptkbp:sideEffect gptkb:hand-foot_syndrome
nausea
vomiting
diarrhea
mucositis
myelosuppression
gptkbp:synonym 5-FU
gptkbp:usedFor gptkb:cancer
gptkb:actinic_keratosis
colorectal cancer
esophageal cancer
pancreatic cancer
bladder cancer
head and neck cancer
gastric cancer
anal cancer
basal cell carcinoma
gptkbp:bfsParent gptkb:Efudex
gptkbp:bfsLayer 7