|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
Yes
|
|
gptkbp:associatedWith
|
Congenital afibrinogenemia
Dysfibrinogenemia
Hypofibrinogenemia
|
|
gptkbp:canonicalSequence
|
Yes
|
|
gptkbp:component
|
Fibrinogen
|
|
gptkbp:database
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:disulfideBond
|
Yes
|
|
gptkbp:domain
|
Coiled coil domain
Fibrinogen C-terminal domain
|
|
gptkbp:EC_number
|
nan
|
|
gptkbp:Entrez_Gene_ID
|
2243
ENSG00000171560
|
|
gptkbp:function
|
Involved in blood clot formation
|
|
gptkbp:gene
|
gptkb:FGA
|
|
gptkbp:glycosylation
|
Yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P02671
|
|
gptkbp:isoformCount
|
2
|
|
gptkbp:latestReleaseVersion
|
2023-06-14
|
|
gptkbp:locatedOnChromosome
|
4q28
|
|
gptkbp:location
|
Secreted
|
|
gptkbp:massSpectrometry
|
Detected
|
|
gptkbp:molecularWeight
|
95 kDa
|
|
gptkbp:mutationAssociatedWith
|
Aα Arg16His associated with afibrinogenemia
R35C associated with dysfibrinogenemia
|
|
gptkbp:name
|
Fibrinogen alpha chain
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mouse Fga
Rat Fga
|
|
gptkbp:pathway
|
Wound healing
Blood coagulation
Platelet activation
|
|
gptkbp:PDB
|
1FZA
1FZC
3GHG
1FZB
|
|
gptkbp:phosphorylates
|
Yes
|
|
gptkbp:postTranslationalModification
|
Cleaved by thrombin to form fibrin
|
|
gptkbp:proteinFamily
|
Fibrinogen alpha/beta/gamma chain family
|
|
gptkbp:RefSeq
|
NP_000499.1
|
|
gptkbp:reviewedBy
|
Yes
|
|
gptkbp:sequence
|
866
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:signalPeptide
|
Yes
|
|
gptkbp:signalSequence
|
1-19
|
|
gptkbp:subunit
|
Forms a hexamer with beta and gamma chains
|
|
gptkbp:tissue_specificity
|
Liver
|
|
gptkbp:UniProtID
|
gptkb:P02671
|
|
gptkbp:bfsParent
|
gptkb:fibrinogen
gptkb:Fibrinogen_Alpha_Chain
gptkb:fibrinopeptide_A
|
|
gptkbp:bfsLayer
|
7
|