|
gptkbp:instanceOf
|
gptkb:protein
blood coagulation factor
|
|
gptkbp:activatedBy
|
gptkb:factor_VIIa-tissue_factor_complex
gptkb:factor_IXa
gptkb:factor_XIa
|
|
gptkbp:alternativeName
|
gptkb:Christmas_factor
|
|
gptkbp:catalyzes
|
activation of factor X
|
|
gptkbp:deficiencyCauses
|
gptkb:hemophilia_B
|
|
gptkbp:discoveredBy
|
gptkb:R.G._Macfarlane
gptkb:Rosalind_Biggs
|
|
gptkbp:discoveredIn
|
1952
|
|
gptkbp:domain
|
EGF-like domain
Gla domain
serine protease domain
|
|
gptkbp:EC_number
|
3.4.21.22
|
|
gptkbp:encodedBy
|
gptkb:F9_gene
|
|
gptkbp:formsComplexWith
|
gptkb:factor_VIIIa
phospholipids
calcium ions
|
|
gptkbp:function
|
blood coagulation
|
|
gptkbp:glycosylation
|
true
|
|
gptkbp:halfLife
|
18-24 hours
|
|
gptkbp:hasTherapeuticForm
|
gptkb:extended_half-life_factor_IX
gptkb:plasma-derived_factor_IX
recombinant factor IX
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
factor IX
|
|
gptkbp:inhibitedBy
|
gptkb:antithrombin
gptkb:protein_Z-dependent_protease_inhibitor
|
|
gptkbp:isVitaminKDependent
|
true
|
|
gptkbp:locatedOnChromosome
|
Xq27.1-q27.2
|
|
gptkbp:location
|
gptkb:plasma
|
|
gptkbp:molecularWeight
|
~55 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hemophilia_B
|
|
gptkbp:OMIM
|
306900
|
|
gptkbp:partOf
|
intrinsic pathway of coagulation
|
|
gptkbp:PDB
|
1PFX
1QFH
1RFN
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
gamma-carboxylation
sulfation
|
|
gptkbp:producedBy
|
liver
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:substrate
|
gptkb:factor_VIIa-tissue_factor_complex
gptkb:factor_XIa
|
|
gptkbp:target
|
antibodies in hemophilia B patients
inhibitors in hemophilia B patients
|
|
gptkbp:UniProtID
|
P00740
|
|
gptkbp:usedInTherapyFor
|
gptkb:hemophilia_B
|
|
gptkbp:bfsParent
|
gptkb:coagulation_factors_II,_VII,_IX,_X
|
|
gptkbp:bfsLayer
|
5
|