|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:activatedBy
|
gptkb:estradiol
estriol
estrone
|
|
gptkbp:binds
|
estrogen
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:encodedBy
|
gptkb:ESR2_gene
ESR1 gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:bone
gptkb:skin
gptkb:pituitary_gland
gptkb:kidney
gptkb:prostate
gptkb:testis
brain
heart
liver
adipose tissue
colon
pancreas
uterus
breast tissue
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
regulate gene expression
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
estrogen receptors
|
|
gptkbp:inhibitedBy
|
aromatase inhibitors
antiestrogens
|
|
gptkbp:location
|
gptkb:cytoplasm
cell nucleus
|
|
gptkbp:regulates
|
transcription of target genes
|
|
gptkbp:role
|
gptkb:cancer
central nervous system
cardiovascular system
reproductive system
bone metabolism
|
|
gptkbp:structure
|
DNA-binding domain
ligand-binding domain
activation function domain
|
|
gptkbp:subspecies
|
ERα
ERβ
|
|
gptkbp:target
|
gptkb:fulvestrant
gptkb:tamoxifen
selective estrogen receptor modulators
|
|
gptkbp:bfsParent
|
gptkb:HGNC:3603
gptkb:Ventromedial_hypothalamus
|
|
gptkbp:bfsLayer
|
8
|