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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
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gptkb:EPO
EPX
eosinophil granule major basic protein 2
|
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gptkbp:associatedWith
|
myeloperoxidase
lactoperoxidase
|
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gptkbp:biologicalProcess
|
peroxidase activity
|
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gptkbp:cellularComponent
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gptkb:cytoplasm
secretory granule
|
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gptkbp:contains_cofactor
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gptkb:hemoglobin
|
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gptkbp:discoveredBy
|
1960s
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gptkbp:EC_number
|
1.11.2.2
|
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gptkbp:expressedIn
|
bone marrow
peripheral blood eosinophils
|
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gptkbp:foundIn
|
eosinophil granulocytes
|
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gptkbp:function
|
catalyzes oxidation of halides and pseudohalides
|
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gptkbp:gene
|
EPX
|
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gptkbp:involves
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gptkb:immune_response
|
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gptkbp:locatedOnChromosome
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gptkb:17q23
|
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gptkbp:molecularWeight
|
~75 kDa
|
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gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1Q3E
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
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gptkbp:produces
|
hypochlorous acid
hypobromous acid
hypoiodous acid
hypohalous acids
hypothiocyanous acid
|
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gptkbp:role
|
asthma
allergic inflammation
eosinophilic disorders
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
hydrogen peroxide
iodide
chloride
bromide
halide ions
thiocyanate
|
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gptkbp:UniProtID
|
P11678
|
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gptkbp:bfsParent
|
gptkb:eosinophils
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
eosinophil peroxidase
|