docetaxel molecule

URI: https://gptkb.org/entity/docetaxel_molecule

GPTKB entity

Statements (53)

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound antineoplastic agent
gptkbp:approvedBy	1995
gptkbp:ATCCode	gptkb:L01CD02
gptkbp:brand	gptkb:Taxotere
gptkbp:CASNumber	gptkb:114977-28-5
gptkbp:chemicalFormula	C43H53NO14
gptkbp:chirality	chiral
gptkbp:contraindication	severe liver impairment
gptkbp:derivedFrom	paclitaxel
gptkbp:developedBy	gptkb:Rhône-Poulenc_Rorer
gptkbp:discoveredIn	1986
gptkbp:eliminationHalfLife	11 hours
https://www.w3.org/2000/01/rdf-schema#label	docetaxel molecule
gptkbp:interactsWith	CYP3A4 inhibitors CYP3A4 inducers
gptkbp:IUPACName	(2R,3S)-N-carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β-20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate
gptkbp:KEGGID	D07775
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	inhibits microtubule depolymerization
gptkbp:meltingPoint	232–234°C
gptkbp:metabolism	liver
gptkbp:molecularWeight	807.88 g/mol
gptkbp:origin	semi-synthetic
gptkbp:patentExpired	2010
gptkbp:pregnancyCategory	D (US)
gptkbp:PubChem_CID	gptkb:CHEMBL92 gptkb:DB01248 148124
gptkbp:riskFactor	may cause cancer toxic to reproduction
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	gptkb:anemia nausea hair loss peripheral neuropathy neutropenia fluid retention
gptkbp:solubility	practically insoluble in water
gptkbp:source	European yew (Taxus baccata)
gptkbp:storage	2–8°C
gptkbp:structureType	taxane
gptkbp:synonym	RP 56976
gptkbp:toxicity	myelosuppression
gptkbp:UNII	699121PHCA
gptkbp:usedFor	gptkb:non-small_cell_lung_cancer gptkb:cancer prostate cancer head and neck cancer gastric cancer
gptkbp:WHOModelListOfEssentialMedicines	included
gptkbp:bfsParent	gptkb:E_ring
gptkbp:bfsLayer	7