Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:anatomy |
neutrophils
|
| gptkbp:application |
defense response
study of immune responses |
| gptkbp:associated_protein |
gptkb:p47phox
|
| gptkbp:associated_with |
chronic granulomatous disease
|
| gptkbp:binding_site |
FAD
|
| gptkbp:biochemical_role |
electron donor
|
| gptkbp:breeding_range |
X chromosome
|
| gptkbp:cellular_function |
regulation of reactive oxygen species
|
| gptkbp:clinical_relevance |
diagnostic marker for CGD
|
| gptkbp:clinical_trial |
important in immune response
ongoing studies for CGD treatment |
| gptkbp:disease_mechanism |
defective superoxide production
|
| gptkbp:diseases |
gptkb:X-linked_chronic_granulomatous_disease
linked to immune system disorders |
| gptkbp:function |
electron transport
|
| gptkbp:function_in_disease |
contributes to immune deficiency
|
| gptkbp:genetic_disorder |
X-linked disorder
|
| gptkbp:genetic_studies |
point mutations
highly conserved among mammals impaired respiratory burst |
| https://www.w3.org/2000/01/rdf-schema#label |
cytochrome b-245 beta chain
|
| gptkbp:initiated_by |
NADPH oxidase inhibitors
|
| gptkbp:interacts_with |
NADPH oxidase subunits
p22phox |
| gptkbp:involved_in |
reactive oxygen species production
|
| gptkbp:is_expressed_in |
myeloid cells
upregulated in activated immune cells |
| gptkbp:location |
cell membrane
|
| gptkbp:modifications |
glycosylation
|
| gptkbp:nutritional_value |
catalyzes electron transfer
cytochrome b domain cytochrome b family localized in phagocytes transmembrane domain with other NADPH oxidase components |
| gptkbp:originated_in |
gptkb:CYBB_gene
|
| gptkbp:orthologs |
found in various species
|
| gptkbp:part_of |
gptkb:NADPH_oxidase_complex
|
| gptkbp:pathway |
NADPH oxidase pathway
inflammation pathway related to chronic granulomatous disease |
| gptkbp:promoter |
gptkb:CYBB
|
| gptkbp:protein_complex |
part of the phagocyte NADPH oxidase complex
|
| gptkbp:protein_expression |
detected in leukocytes
|
| gptkbp:protein_family_classification |
NADPH oxidase family
|
| gptkbp:protein_type |
cytochrome protein
|
| gptkbp:regulatory_compliance |
regulated by cytokines
|
| gptkbp:research |
oxidoreductase activity
|
| gptkbp:research_focus |
gene therapy for CGD
|
| gptkbp:research_importance |
target for drug development
|
| gptkbp:role_in_cell |
oxidative stress response
|
| gptkbp:sequence_length |
approximately 200 amino acids
|
| gptkbp:subunit |
gptkb:cytochrome_b-245
|
| gptkbp:targets |
for immune disorders
|
| gptkbp:theory |
heme
|
| gptkbp:type |
membrane protein
|
| gptkbp:weight |
approximately 30 k Da
|
| gptkbp:bfsParent |
gptkb:cytochrome_b-245_alpha_chain
|
| gptkbp:bfsLayer |
7
|