Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activityUnit |
IU/L
|
| gptkbp:alsoKnownAs |
gptkb:creatine_kinase
|
| gptkbp:catalyzes |
transfer of phosphate group from ATP to creatine
|
| gptkbp:cofactor |
magnesium ion
|
| gptkbp:discoveredBy |
Nathanson and colleagues
|
| gptkbp:discoveredIn |
1960
|
| gptkbp:EC_number |
2.7.3.2
|
| gptkbp:foundIn |
gptkb:skeletal_muscle
brain tissue heart tissue |
| gptkbp:gene |
gptkb:CKMT1
gptkb:CKMT2 gptkb:CKM gptkb:CKB |
| https://www.w3.org/2000/01/rdf-schema#label |
creatine phosphokinase
|
| gptkbp:inhibitedBy |
high concentrations of ADP
|
| gptkbp:locatedOnChromosome |
chromosome 14 (CKB)
chromosome 15 (CKMT2) chromosome 19 (CKM) chromosome 5 (CKMT1) |
| gptkbp:location |
mitochondria
cytosol |
| gptkbp:marking |
gptkb:trauma
gptkb:statin-induced_myopathy myocardial infarction stroke hypothyroidism seizures malignant hyperthermia muscular dystrophy alcohol abuse intensive exercise muscle damage myositis |
| gptkbp:measures |
blood test
|
| gptkbp:molecularWeight |
approximately 82 kDa
|
| gptkbp:product |
gptkb:ADP
gptkb:phosphocreatine |
| gptkbp:significance |
elevated in myocardial infarction
elevated in muscle diseases |
| gptkbp:structure |
dimer
|
| gptkbp:substrate |
gptkb:ATP
gptkb:creatine |
| gptkbp:subunit |
gptkb:CK-BB
gptkb:CK-MM gptkb:CK-MB |
| gptkbp:usedFor |
diagnosis of heart attack
diagnosis of muscular dystrophy diagnosis of rhabdomyolysis |
| gptkbp:bfsParent |
gptkb:Creatine_kinase
|
| gptkbp:bfsLayer |
7
|