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gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activityUnit
|
IU/L
|
|
gptkbp:alsoKnownAs
|
gptkb:creatine_kinase
|
|
gptkbp:catalyzes
|
transfer of phosphate group from ATP to creatine
|
|
gptkbp:cofactor
|
magnesium ion
|
|
gptkbp:discoveredBy
|
Nathanson and colleagues
|
|
gptkbp:discoveredIn
|
1960
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|
gptkbp:EC_number
|
2.7.3.2
|
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gptkbp:foundIn
|
gptkb:skeletal_muscle
brain tissue
heart tissue
|
|
gptkbp:gene
|
gptkb:CKMT1
gptkb:CKMT2
gptkb:CKM
gptkb:CKB
|
|
gptkbp:inhibitedBy
|
high concentrations of ADP
|
|
gptkbp:locatedOnChromosome
|
chromosome 14 (CKB)
chromosome 15 (CKMT2)
chromosome 19 (CKM)
chromosome 5 (CKMT1)
|
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gptkbp:location
|
mitochondria
cytosol
|
|
gptkbp:marking
|
gptkb:trauma
gptkb:statin-induced_myopathy
gptkb:muscular_dystrophy
myocardial infarction
stroke
hypothyroidism
seizures
malignant hyperthermia
alcohol abuse
intensive exercise
muscle damage
myositis
|
|
gptkbp:measures
|
gptkb:blood_test
|
|
gptkbp:molecularWeight
|
approximately 82 kDa
|
|
gptkbp:product
|
gptkb:ADP
gptkb:phosphocreatine
|
|
gptkbp:significance
|
elevated in myocardial infarction
elevated in muscle diseases
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:creatine
|
|
gptkbp:subunit
|
gptkb:CK-BB
gptkb:CK-MM
gptkb:CK-MB
|
|
gptkbp:usedFor
|
diagnosis of heart attack
diagnosis of muscular dystrophy
diagnosis of rhabdomyolysis
|
|
gptkbp:bfsParent
|
gptkb:creatine_kinase
gptkb:Creatine_kinase
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
creatine phosphokinase
|