|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activity_measured_in
|
IU/L
|
|
gptkbp:alternativeName
|
gptkb:CK
gptkb:CPK
gptkb:creatine_phosphokinase
|
|
gptkbp:catalyzes
|
transfer of phosphate group from ATP to creatine
|
|
gptkbp:decreased_by
|
muscle wasting
|
|
gptkbp:discoveredBy
|
1927
|
|
gptkbp:EC_number
|
2.7.3.2
|
|
gptkbp:encodedBy
|
CKB gene (brain)
CKM gene (muscle)
CKMT1 gene (mitochondrial)
CKMT2 gene (mitochondrial)
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
brain tissue
heart tissue
|
|
gptkbp:gene
|
gptkb:CK
|
|
gptkbp:has_isoenzyme
|
gptkb:CK-BB
gptkb:CK-MM
gptkb:CK-MB
|
|
gptkbp:hasBiomarker
|
myocardial infarction
muscle damage
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
creatine kinase
|
|
gptkbp:increased_by
|
strenuous exercise
muscle trauma
|
|
gptkbp:inhibitedBy
|
high levels of ADP
|
|
gptkbp:measures
|
blood tests
|
|
gptkbp:molecularWeight
|
approximately 82 kDa
|
|
gptkbp:presentIn
|
mitochondria
cytosol
|
|
gptkbp:product
|
gptkb:ADP
gptkb:phosphocreatine
|
|
gptkbp:reference_range_(adult_female)
|
38–176 IU/L
|
|
gptkbp:reference_range_(adult_male)
|
52–336 IU/L
|
|
gptkbp:relatedTo
|
energy metabolism
phosphagen system
|
|
gptkbp:significance
|
elevated in muscular dystrophy
elevated in myocarditis
elevated in rhabdomyolysis
elevated in stroke
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:ATP
gptkb:creatine
|
|
gptkbp:systematicName
|
ATP:creatine N-phosphotransferase
|
|
gptkbp:UniProtID
|
P06732 (human CK-MB)
P12277 (human CK-BB)
P12277 (human CK-MM)
|
|
gptkbp:used_in_diagnosis_of
|
myocardial infarction
muscular dystrophy
|
|
gptkbp:bfsParent
|
gptkb:CK-MB
gptkb:CHEBI:15765
gptkb:phosphotransferase
|
|
gptkbp:bfsLayer
|
7
|