conventional amphotericin B

URI: https://gptkb.org/entity/conventional_amphotericin_B
GPTKB entity
Statements (39)
Predicate Object
gptkbp:instanceOf antifungal medication
polyene antifungal
gptkbp:activeIngredient gptkb:amphotericin_B
gptkbp:alternativeTo gptkb:liposomal_amphotericin_B
gptkb:amphotericin_B_colloidal_dispersion
gptkb:amphotericin_B_lipid_complex
gptkbp:ATCCode gptkb:J02AA01
gptkbp:CASNumber gptkb:1397-89-3
gptkbp:contraindication hypersensitivity to amphotericin B
gptkbp:discoveredIn 1955
gptkbp:drugClass antifungal
gptkbp:eliminationHalfLife 15 days
gptkbp:excretion renal
biliary
gptkbp:form deoxycholate formulation
gptkbp:hasMolecularFormula C47H73NO17
https://www.w3.org/2000/01/rdf-schema#label conventional amphotericin B
gptkbp:indication gptkb:mucormycosis
candidiasis
aspergillosis
cryptococcal meningitis
systemic fungal infections
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction binds to ergosterol in fungal cell membrane
forms pores in fungal cell membrane
gptkbp:metabolism hepatic
gptkbp:origin gptkb:Streptomyces_nodosus
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding >90%
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect gptkb:anemia
hypokalemia
nephrotoxicity
infusion-related reactions
gptkbp:WHOModelListOfEssentialMedicines true
gptkbp:bfsParent gptkb:AmBisome
gptkb:Amphotec
gptkb:Amphotericin_B
gptkbp:bfsLayer 7