|
gptkbp:instanceOf
|
antifungal medication
polyene antifungal
|
|
gptkbp:administeredBy
|
intravenous infusion
topical application
|
|
gptkbp:ATCCode
|
gptkb:J02AA01
|
|
gptkbp:brand
|
gptkb:Abelcet
gptkb:AmBisome
gptkb:Amphotec
gptkb:Fungizone
|
|
gptkbp:CASNumber
|
gptkb:1397-89-3
|
|
gptkbp:chemicalFormula
|
C47H73NO17
|
|
gptkbp:contraindication
|
hypersensitivity to amphotericin B
|
|
gptkbp:discoveredBy
|
gptkb:Squibb_Institute_for_Medical_Research
|
|
gptkbp:discoveredIn
|
1955
|
|
gptkbp:drugClass
|
antifungal
polyene
|
|
gptkbp:eliminationHalfLife
|
15 days
|
|
gptkbp:excretion
|
urine
bile
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amphotericin B
|
|
gptkbp:includedIn
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:KEGGID
|
gptkb:D00203
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to ergosterol in fungal cell membranes
forms pores in fungal cell membranes
|
|
gptkbp:meltingPoint
|
170°C
|
|
gptkbp:MeSH_ID
|
gptkb:D000900
|
|
gptkbp:metabolism
|
unknown
|
|
gptkbp:molecularWeight
|
924.08 g/mol
|
|
gptkbp:origin
|
gptkb:Streptomyces_nodosus
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL521
gptkb:DB00681
4447572
5280965
|
|
gptkbp:routeOfAdministration
|
topical
intravenous
|
|
gptkbp:sideEffect
|
gptkb:anemia
fever
chills
hypokalemia
nephrotoxicity
|
|
gptkbp:synonym
|
gptkb:Abelcet
gptkb:AmBisome
gptkb:Amphotec
gptkb:Fungizone
|
|
gptkbp:UNII
|
J6292F8L3D
|
|
gptkbp:usedFor
|
treatment of fungal infections
treatment of leishmaniasis
|
|
gptkbp:bfsParent
|
gptkb:Cryptococcosis
gptkb:Histoplasmosis
gptkb:Candida
gptkb:Leishmania_donovani
gptkb:Leishmaniasis
|
|
gptkbp:bfsLayer
|
5
|