amphotericin B lipid complex

URI: https://gptkb.org/entity/amphotericin_B_lipid_complex
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf antifungal medication
lipid formulation
gptkbp:activeIngredient gptkb:amphotericin_B
gptkbp:administeredBy gptkb:physician
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:J02AA01
gptkbp:contains gptkb:dimyristoyl_phosphatidylcholine
gptkb:dimyristoyl_phosphatidylglycerol
gptkbp:developedToReduce renal toxicity
gptkbp:eliminationHalfLife ~7 hours
gptkbp:form suspension for injection
lipid complex
https://www.w3.org/2000/01/rdf-schema#label amphotericin B lipid complex
gptkbp:marketedAs gptkb:Abelcet
gptkbp:mechanismOfAction binds to ergosterol in fungal cell membrane
causes cell membrane permeability
gptkbp:notRecommendedFor patients with hypersensitivity to amphotericin B
gptkbp:pregnancyCategory B (US)
gptkbp:reducedToxicityComparedTo gptkb:conventional_amphotericin_B
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect gptkb:anemia
hypokalemia
nephrotoxicity
infusion-related reactions
gptkbp:storage 2-8°C
gptkbp:usedFor gptkb:cryptococcosis
gptkb:histoplasmosis
gptkb:zygomycosis
candidiasis
aspergillosis
blastomycosis
systemic fungal infections
gptkbp:bfsParent gptkb:Abelcet
gptkb:Amphotericin_B
gptkbp:bfsLayer 7