amphotericin B lipid complex

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:antifungal_medication gptkb:lipid_formulation
gptkbp:activeIngredient	gptkb:amphotericin_B
gptkbp:administeredBy	gptkb:physician
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	gptkb:J02AA01
gptkbp:contains	gptkb:dimyristoyl_phosphatidylcholine gptkb:dimyristoyl_phosphatidylglycerol
gptkbp:developedToReduce	renal toxicity
gptkbp:eliminationHalfLife	~7 hours
gptkbp:form	suspension for injection lipid complex
gptkbp:marketedAs	gptkb:Abelcet
gptkbp:mechanismOfAction	binds to ergosterol in fungal cell membrane causes cell membrane permeability
gptkbp:notRecommendedFor	patients with hypersensitivity to amphotericin B
gptkbp:pregnancyCategory	B (US)
gptkbp:reducedToxicityComparedTo	gptkb:conventional_amphotericin_B
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	gptkb:anemia hypokalemia nephrotoxicity infusion-related reactions
gptkbp:storage	2-8°C
gptkbp:usedFor	gptkb:cryptococcosis gptkb:histoplasmosis gptkb:zygomycosis candidiasis aspergillosis blastomycosis systemic fungal infections
gptkbp:bfsParent	gptkb:Abelcet
gptkbp:bfsLayer	7
http://www.w3.org/2000/01/rdf-schema#label	amphotericin B lipid complex