|
gptkbp:instanceOf
|
gptkb:protein
complement system component
|
|
gptkbp:alternativeName
|
C3
complement C3
complement component 3
|
|
gptkbp:associatedWith
|
autoimmune diseases
complement deficiency
infections susceptibility
|
|
gptkbp:cleavage
|
gptkb:C3b
C3 convertase
C3a
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:encodedBy
|
C3 gene
|
|
gptkbp:expressedIn
|
liver
macrophages
monocytes
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
other mammals
|
|
gptkbp:function
|
immune response
opsonization
inflammation mediation
activation of complement system
|
|
gptkbp:HGNC_ID
|
1318
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
complement component C3
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.3
|
|
gptkbp:location
|
blood plasma
|
|
gptkbp:molecularWeight
|
~187 kDa
|
|
gptkbp:OMIM
|
120700
|
|
gptkbp:PDB
|
2A73
2HR0
2WIN
|
|
gptkbp:postTranslationalModification
|
cleavage
glycosylation
|
|
gptkbp:predecessor
|
gptkb:C3b
C3a
|
|
gptkbp:role
|
gptkb:lectin_pathway
alternative pathway
classical pathway
|
|
gptkbp:structure
|
alpha and beta chains
|
|
gptkbp:subunit
|
alpha chain
beta chain
|
|
gptkbp:type
|
gptkb:membrane_attack_complex
gptkb:factor_B
gptkb:factor_H
C3 convertase
C5 convertase
factor I
properdin
|
|
gptkbp:UniProtID
|
P01024
|
|
gptkbp:bfsParent
|
gptkb:Mannose-binding_lectin
|
|
gptkbp:bfsLayer
|
7
|