Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
combination drug
|
| gptkbp:activeIngredient |
gptkb:codeine
acetaminophen |
| gptkbp:approvedBy |
1960s
|
| gptkbp:ATCCode |
N02AJ06
|
| gptkbp:brand |
gptkb:Tylenol_with_Codeine
|
| gptkbp:contraindication |
children under 12
severe respiratory depression hypersensitivity to codeine or acetaminophen |
| gptkbp:controlledSubstanceSchedule |
gptkb:Schedule_III_(US)
|
| gptkbp:countryOfOperation |
gptkb:Australia
gptkb:Canada gptkb:United_States |
| gptkbp:drugClass |
antitussive
opioid analgesic combination |
| gptkbp:drugInteraction |
gptkb:beer
gptkb:MAO_inhibitors gptkb:CNS_depressants other opioids |
| gptkbp:excretion |
gptkb:kidney
|
| gptkbp:form |
gptkb:tablet
elixir #2 (acetaminophen 300 mg + codeine 15 mg) #3 (acetaminophen 300 mg + codeine 30 mg) #4 (acetaminophen 300 mg + codeine 60 mg) |
| https://www.w3.org/2000/01/rdf-schema#label |
Tylenol with Codeine
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:manufacturer |
gptkb:Johnson_&_Johnson
|
| gptkbp:mechanismOfAction |
acetaminophen inhibits prostaglandin synthesis
codeine acts as a mu-opioid receptor agonist |
| gptkbp:metabolism |
liver
|
| gptkbp:overdoseSymptoms |
respiratory depression
acetaminophen toxicity |
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:prescribes |
severe pain
moderate pain pain not controlled by non-opioid analgesics |
| gptkbp:riskFactor |
addiction
respiratory depression liver damage |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
vomiting constipation dizziness drowsiness |
| gptkbp:usedFor |
pain relief
cough suppression |
| gptkbp:bfsParent |
gptkb:Codeine
gptkb:codeine |
| gptkbp:bfsLayer |
6
|