|
gptkbp:instanceOf
|
gptkb:combination_drug
|
|
gptkbp:activeIngredient
|
gptkb:codeine
acetaminophen
|
|
gptkbp:approvedBy
|
1960s
|
|
gptkbp:ATCCode
|
N02AJ06
|
|
gptkbp:brand
|
gptkb:Tylenol_with_Codeine
|
|
gptkbp:contraindication
|
children under 12
severe respiratory depression
hypersensitivity to codeine or acetaminophen
|
|
gptkbp:controlledSubstanceSchedule
|
gptkb:Schedule_III_(US)
|
|
gptkbp:countryOfOperation
|
gptkb:Australia
gptkb:Canada
gptkb:United_States
|
|
gptkbp:drugClass
|
gptkb:opioid
gptkb:antitussive
analgesic combination
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
other opioids
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:form
|
gptkb:tablet
elixir
#2 (acetaminophen 300 mg + codeine 15 mg)
#3 (acetaminophen 300 mg + codeine 30 mg)
#4 (acetaminophen 300 mg + codeine 60 mg)
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Johnson_&_Johnson
|
|
gptkbp:mechanismOfAction
|
acetaminophen inhibits prostaglandin synthesis
codeine acts as a mu-opioid receptor agonist
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:overdoseSymptoms
|
respiratory depression
acetaminophen toxicity
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescribes
|
severe pain
moderate pain
pain not controlled by non-opioid analgesics
|
|
gptkbp:riskFactor
|
addiction
respiratory depression
liver damage
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
constipation
dizziness
drowsiness
|
|
gptkbp:usedFor
|
pain relief
cough suppression
|
|
gptkbp:bfsParent
|
gptkb:Codeine
gptkb:codeine
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tylenol with Codeine
|