clear cell renal carcinoma

URI: https://gptkb.org/entity/clear_cell_renal_carcinoma
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
renal cell carcinoma
gptkbp:affects gptkb:kidney
gptkbp:alsoKnownAs gptkb:ccRCC
gptkbp:associatedWith gptkb:VHL_gene_mutation
gptkbp:canBeSporadic yes
gptkbp:canMetastasizeTo brain
lungs
liver
bones
gptkbp:commonIn males
gptkbp:diagnosedBy imaging
biopsy
gptkbp:firstDescribed 1883
Paul Grawitz
gptkbp:hasGeneticAlteration chromosome 3p deletion
gptkbp:hereditary yes
gptkbp:hereditarySyndrome gptkb:von_Hippel-Lindau_disease
gptkbp:histology clear cytoplasm
delicate vasculature
https://www.w3.org/2000/01/rdf-schema#label clear cell renal carcinoma
gptkbp:ICD-10_code gptkb:C64
gptkbp:immunohistochemistryMarker gptkb:CD10
gptkb:CAIX
gptkb:PAX8
gptkb:vimentin
gptkbp:mostCommonTypeOf renal cell carcinoma
gptkbp:originatedIn renal tubular epithelial cells
gptkbp:paraneoplasticSyndrome gptkb:hypercalcemia
gptkb:Stauffer_syndrome
hypertension
polycythemia
gptkbp:peakIncidenceAge 60-70 years
gptkbp:prognosis gptkb:theatre
grade
metastasis
gptkbp:riskFactor family history
obesity
smoking
hypertension
chronic kidney disease
gptkbp:symptom hematuria
abdominal mass
flank pain
gptkbp:treatment surgery
radiation therapy
immunotherapy
targeted therapy
gptkbp:bfsParent gptkb:Von_Hippel-Lindau_Disease
gptkbp:bfsLayer 7