Statements (76)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:Renal_cell_carcinoma
|
| gptkbp:affects |
VHL protein function
|
| gptkbp:analyzes |
molecular biology
risk assessment therapeutic strategies pharmacogenomics gene therapy approaches |
| gptkbp:associated_with |
gptkb:Von_Hippel-Lindau_disease
|
| gptkbp:can_be |
surgical complications
diagnostic challenges psychosocial impacts adrenal tumors |
| gptkbp:can_lead_to |
gptkb:hemangioblastomas
systemic complications central nervous system tumors neuroendocrine tumors quality of life concerns pancreatic cysts |
| gptkbp:caused_by |
tumor formation
retinal tumors |
| gptkbp:descendant |
autosomal dominant inheritance
|
| gptkbp:examines |
patient registries
longitudinal studies clinical management oncology research pathology studies |
| https://www.w3.org/2000/01/rdf-schema#label |
VHL gene mutation
|
| gptkbp:investment |
gptkb:healthcare_organization
|
| gptkbp:involves |
chromosome 3p25.3
|
| gptkbp:is_analyzed_in |
genomic studies
clinical significance mutation spectrum |
| gptkbp:is_associated_with |
clinical outcomes
increased surveillance multidisciplinary care survivorship issues vascular tumors multiple tumors early onset of symptoms metabolic dysregulation |
| gptkbp:is_characterized_by |
loss of function
|
| gptkbp:is_considered |
healthcare policies
genetic counseling treatment planning patient prognosis |
| gptkbp:is_considered_as |
a hereditary condition
|
| gptkbp:is_linked_to |
gptkb:pheochromocytomas
genetic diversity tumor heterogeneity tumor microenvironment tumor suppressor genes cellular signaling pathways endocrine tumors patient education. cystic lesions |
| gptkbp:is_monitored_by |
gptkb:Photographer
|
| gptkbp:is_often_used_in |
certain populations
|
| gptkbp:is_part_of |
cancer research initiatives
cancer genetics hereditary cancer syndromes cancer prevention efforts cancer predisposition syndromes VHL syndrome |
| gptkbp:is_recognized_by |
DNA sequencing
|
| gptkbp:is_related_to |
angiogenesis
hypoxia-inducible factors |
| gptkbp:is_studied_in |
biomarker discovery
epidemiological studies translational research therapeutic targets clinical genetics |
| gptkbp:is_subject_to |
clinical trials
|
| gptkbp:recognizes |
genetic testing
|
| gptkbp:treatment |
surgical intervention
|