ciliary neurotrophic factor

URI: https://gptkb.org/entity/ciliary_neurotrophic_factor
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:CNTF
gptkbp:alternativeName gptkb:CNTF
Ciliary neurotrophic factor polypeptide
Ciliary neurotrophic factor precursor
gptkbp:clinicalTrialPhase gptkb:ALS
retinitis pigmentosa
gptkbp:discoveredBy 1980s
gptkbp:Entrez_Gene_ID 1270
gptkbp:expressedIn glial cells
Schwann cells
astrocytes
gptkbp:foundIn humans
mice
rats
gptkbp:function growth factor
supports survival of neurons
promotes differentiation of neurons
gptkbp:gene gptkb:CNTF
gptkbp:HGNC_ID HGNC:2151
https://www.w3.org/2000/01/rdf-schema#label ciliary neurotrophic factor
gptkbp:locatedOnChromosome human chromosome 11q12.1
gptkbp:molecularWeight 22 kDa
gptkbp:OMIM 162000
gptkbp:PDB 1CNT
gptkbp:promotion myelination
neuronal survival
axon regeneration
gptkbp:recipient CNTFR
CNTF receptor complex
gptkbp:relatedTo gptkb:interleukin-6_family
gptkb:leukemia_inhibitory_factor
gptkbp:sideEffect fever
muscle pain
weight loss
gptkbp:structure cytokine
gptkbp:UniProtID P26441
gptkbp:used_in_research_for gptkb:ALS
multiple sclerosis
neurodegenerative diseases
retinal degeneration
gptkbp:bfsParent gptkb:gp130_receptor
gptkbp:bfsLayer 6