|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
gptkb:neomycin
magnesium ions
gentamicin
extracellular calcium ions
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:hypercalcemia
gptkb:hypoparathyroidism
hypocalcemia
hyperparathyroidism
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
7-transmembrane domain
Venus flytrap domain
|
|
gptkbp:encodedBy
|
CASR gene
|
|
gptkbp:enemyOf
|
NPS 2143
cinacalcet
etelcalcetide
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skin
colon
thyroid gland
breast tissue
|
|
gptkbp:foundIn
|
gptkb:bone
gptkb:kidney
brain
gastrointestinal tract
parathyroid gland
|
|
gptkbp:function
|
regulation of extracellular calcium concentration
|
|
gptkbp:HGNC_ID
|
1514
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
calcium-sensing receptor
|
|
gptkbp:inhibitedBy
|
calcilytics
|
|
gptkbp:locatedOnChromosome
|
3q13.3-q21
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autosomal_dominant_hypocalcemia
gptkb:familial_hypocalciuric_hypercalcemia
gptkb:neonatal_severe_hyperparathyroidism
|
|
gptkbp:OMIM
|
601199
|
|
gptkbp:PDB
|
5FBH
5FBJ
5FBK
5K5S
|
|
gptkbp:regulates
|
parathyroid hormone secretion
renal calcium reabsorption
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
gptkb:Golgi_apparatus
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
P41180
|
|
gptkbp:bfsParent
|
gptkb:CASR
|
|
gptkbp:bfsLayer
|
7
|