|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
ARG2 protein
mitochondrial arginase
type II arginase
|
|
gptkbp:associatedWith
|
asthma
atherosclerosis
hypertension
|
|
gptkbp:biologicalProcess
|
nitrogen metabolism
arginase activity
polyamine biosynthesis
|
|
gptkbp:cofactor
|
manganese
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.5.3.1
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000118777
GC14M067282
|
|
gptkbp:expressedIn
|
gptkb:kidney
gptkb:prostate
gptkb:small_intestine
brain
macrophages
|
|
gptkbp:function
|
catalyzes hydrolysis of arginine to ornithine and urea
|
|
gptkbp:gene
|
gptkb:ARG2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:663
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
arginase 2
|
|
gptkbp:inhibitedBy
|
Nω-hydroxy-nor-arginine (nor-NOHA)
S-(2-boronoethyl)-L-cysteine (BEC)
|
|
gptkbp:length
|
354
|
|
gptkbp:locatedOnChromosome
|
14q24.1
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
38 kDa
|
|
gptkbp:OMIM
|
107832
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Arg2
|
|
gptkbp:PDB
|
3H7L
|
|
gptkbp:product
|
gptkb:urea
gptkb:L-ornithine
|
|
gptkbp:proteinFamily
|
arginase family
|
|
gptkbp:RefSeq
|
NM_001172
|
|
gptkbp:regulates
|
regulated by cytokines
induced by hypoxia
|
|
gptkbp:related_to_pathway
|
gptkb:urea_cycle
arginine and proline metabolism
|
|
gptkbp:substrate
|
gptkb:L-arginine
|
|
gptkbp:UniProtID
|
P78540
|
|
gptkbp:bfsParent
|
gptkb:arginase
|
|
gptkbp:bfsLayer
|
6
|