angiotensin I converting enzyme
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alsoKnownAs |
gptkb:ACE
|
| gptkbp:discoveredBy |
gptkb:Leonard_T._Skeggs,_Jr.
|
| gptkbp:EC_number |
3.4.15.1
|
| gptkbp:foundIn |
gptkb:cancer
endothelial cells |
| gptkbp:function |
inactivates bradykinin
converts angiotensin I to angiotensin II |
| gptkbp:gene |
gptkb:ACE
|
| gptkbp:GO_term |
GO:0004190
|
| https://www.w3.org/2000/01/rdf-schema#label |
angiotensin I converting enzyme
|
| gptkbp:inhibitedBy |
ACE inhibitors
|
| gptkbp:locatedOnChromosome |
gptkb:17q23.3
|
| gptkbp:molecularWeight |
~150 kDa
|
| gptkbp:OMIM |
106180
|
| gptkbp:role |
gptkb:renin-angiotensin_system
blood pressure regulation |
| gptkbp:significance |
target for antihypertensive drugs
|
| gptkbp:structure |
zinc metallopeptidase
|
| gptkbp:UniProtID |
P12821
|
| gptkbp:bfsParent |
gptkb:ACE_gene
|
| gptkbp:bfsLayer |
7
|