amyotrophic lateral sclerosis (ALS)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease motor neuron disease
gptkbp:affects	lower motor neurons motor neurons upper motor neurons
gptkbp:alsoKnownAs	gptkb:Lou_Gehrig's_disease
gptkbp:averageSurvivalAfterDiagnosis	2 to 5 years
gptkbp:awarenessCampaign	gptkb:ALS_Ice_Bucket_Challenge
gptkbp:casualties	yes
gptkbp:cause	difficulty breathing difficulty speaking difficulty swallowing muscle atrophy muscle weakness
gptkbp:compatibleWith	sensory nerves cognitive function (in most cases)
gptkbp:complication	gptkb:pneumonia malnutrition respiratory failure
gptkbp:diagnosedBy	gptkb:electromyography_(EMG) MRI clinical examination nerve conduction studies
gptkbp:firstDescribed	gptkb:Jean-Martin_Charcot 1869
gptkbp:hereditaryCases	5-10%
https://www.w3.org/2000/01/rdf-schema#label	amyotrophic lateral sclerosis (ALS)
gptkbp:ICD-10_code	G12.2
gptkbp:incidence	about 2 per 100,000 people per year
gptkbp:MeSH_ID	D000690
gptkbp:mutationAssociatedWith	gptkb:C9orf72 gptkb:FUS gptkb:SOD1 gptkb:TARDBP
gptkbp:notablePatient	gptkb:Stephen_Hawking gptkb:Lou_Gehrig
gptkbp:OMIM	105400
gptkbp:onset	adult
gptkbp:prevalence	rare
gptkbp:progression	progressive
gptkbp:researchInterest	stem cell therapy gene therapy disease-modifying drugs
gptkbp:riskFactor	age family history male sex
gptkbp:sporadicCases	90-95%
gptkbp:symptom	paralysis spasticity muscle cramps fasciculations
gptkbp:treatment	gptkb:edaravone gptkb:riluzole supportive care
gptkbp:bfsParent	gptkb:Sidney_Osborn gptkb:Cytokinetics
gptkbp:bfsLayer	6