|
gptkbp:instanceOf
|
gptkb:antibiotic
|
|
gptkbp:actsOn
|
bacterial ribosome
|
|
gptkbp:administeredBy
|
intramuscular injection
intravenous injection
|
|
gptkbp:approvedBy
|
gptkb:United_States
|
|
gptkbp:ATCCode
|
J01GB06
|
|
gptkbp:brand
|
Amikacin Sulfate
Amikin
|
|
gptkbp:CASNumber
|
37517-28-5
|
|
gptkbp:chemicalFormula
|
C22H43N5O13
|
|
gptkbp:contraindication
|
hypersensitivity to aminoglycosides
|
|
gptkbp:developedBy
|
gptkb:Bristol-Myers_Squibb
|
|
gptkbp:discoveredIn
|
1972
|
|
gptkbp:effect
|
gptkb:Acinetobacter
gptkb:Pseudomonas_aeruginosa
gptkb:Bacteria
gptkb:Klebsiella_pneumoniae
Gram-negative bacteria
|
|
gptkbp:eliminatedIn
|
renal
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:halfLife
|
2-3 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amikacin
|
|
gptkbp:KEGGID
|
D07452
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits protein synthesis
|
|
gptkbp:MeSH_ID
|
D000653
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
585.6 g/mol
|
|
gptkbp:monitors
|
renal function
serum drug levels
|
|
gptkbp:notEffectiveAgainst
|
anaerobic bacteria
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1201217
37768
DB00479
|
|
gptkbp:riskFactor
|
hearing loss
kidney damage
|
|
gptkbp:sideEffect
|
nephrotoxicity
ototoxicity
neuromuscular blockade
|
|
gptkbp:UNII
|
X0TQ84G6X6
|
|
gptkbp:usedFor
|
sepsis
urinary tract infections
bacterial infections
intra-abdominal infections
bone and joint infections
tuberculosis (second-line)
|
|
gptkbp:usedIn
|
hospital settings
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Aminoglycosides
|
|
gptkbp:bfsLayer
|
5
|