|
gptkbp:instanceOf
|
antibiotic class
|
|
gptkbp:administeredBy
|
topical
intramuscular
intravenous
|
|
gptkbp:contraindication
|
gptkb:myasthenia_gravis
pregnancy
|
|
gptkbp:discoveredIn
|
1940s
|
|
gptkbp:eliminatedIn
|
renal excretion
|
|
gptkbp:example
|
gptkb:kanamycin
gptkb:tobramycin
gptkb:neomycin
gptkb:amikacin
gentamicin
streptomycin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Aminoglycosides
|
|
gptkbp:mechanismOfAction
|
inhibit protein synthesis
|
|
gptkbp:monitors
|
serum drug levels
|
|
gptkbp:notEffectiveAgainst
|
anaerobic bacteria
intracellular pathogens
|
|
gptkbp:producedBy
|
gptkb:Streptomyces_species
gptkb:Micromonospora_species
|
|
gptkbp:resistantTo
|
altered ribosomal binding site
enzymatic modification
reduced uptake
|
|
gptkbp:sideEffect
|
nephrotoxicity
ototoxicity
neuromuscular blockade
|
|
gptkbp:spectrumOfActivity
|
gram-negative bacteria
some gram-positive bacteria
|
|
gptkbp:target
|
gptkb:30S_ribosomal_subunit
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOStatus
|
gptkb:World_Health_Organization_List_of_Essential_Medicines
|
|
gptkbp:bfsParent
|
gptkb:Antibiotics
|
|
gptkbp:bfsLayer
|
4
|