|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:administered_by
|
intravenous injection
|
|
gptkbp:antimicrobial_activity
|
broad spectrum
|
|
gptkbp:approves
|
gptkb:1955
|
|
gptkbp:brand
|
gptkb:Cosmegen
|
|
gptkbp:casnumber
|
50-76-0
|
|
gptkbp:chemical_formula
|
C62 H86 N12 O16 S
|
|
gptkbp:class
|
polypeptide antibiotic
|
|
gptkbp:clinical_use
|
gptkb:rhabdomyosarcoma
gptkb:gestational_trophoblastic_neoplasia
gptkb:Oncology
gptkb:Wilms_tumor
|
|
gptkbp:composed_by
|
fermentation
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active infections
severe liver disease
|
|
gptkbp:discovered_by
|
gptkb:Selman_Waksman
|
|
gptkbp:discovery_year
|
1940s
|
|
gptkbp:dissolved
|
soluble in water
soluble in ethanol
insoluble in ether
|
|
gptkbp:excretion
|
urine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
actinomycin D
|
|
gptkbp:interacts_with
|
gptkb:cyclophosphamide
gptkb:doxorubicin
radiation therapy
|
|
gptkbp:lifespan
|
15-36 hours
|
|
gptkbp:mechanism_of_action
|
inhibits RNA synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:origin
|
natural product
|
|
gptkbp:produced_by
|
gptkb:Streptomyces_parvulus
|
|
gptkbp:related_to
|
dactinomycin
|
|
gptkbp:research
|
molecular biology
gene expression studies
cell cycle studies
apoptosis research
DNA replication studies
|
|
gptkbp:safety
|
Pregnancy Category D
|
|
gptkbp:sensitivity
|
gptkb:yeast
gram-positive bacteria
gram-negative bacteria
mycobacteria
|
|
gptkbp:side_effect
|
nausea
hair loss
bone marrow suppression
mouth sores
|
|
gptkbp:structure
|
linear polypeptide
|
|
gptkbp:targets
|
gptkb:Biology
gptkb:yeast
cancer cells
rapidly dividing cells
|
|
gptkbp:used_for
|
gptkb:cancer_treatment
|
|
gptkbp:weight
|
1255.5 g/mol
|
|
gptkbp:bfsParent
|
gptkb:RNA_Polymerase_I
|
|
gptkbp:bfsLayer
|
5
|