Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:acetylcholinesterase
|
| gptkbp:discoveredBy |
gptkb:Henry_Hallett_Dale
|
| gptkbp:EC_number |
3.1.1.7
|
| gptkbp:foundIn |
central nervous system
peripheral nervous system neuromuscular junction |
| gptkbp:function |
hydrolyzes acetylcholine
|
| gptkbp:gene |
gptkb:ACHE
|
| https://www.w3.org/2000/01/rdf-schema#label |
acetylcholine esterase
|
| gptkbp:inhibitedBy |
gptkb:organophosphates
carbamates |
| gptkbp:medicalUse |
target for Alzheimer's disease drugs
|
| gptkbp:molecularWeight |
~70 kDa
|
| gptkbp:product |
gptkb:choline
acetate |
| gptkbp:requires |
termination of synaptic transmission
|
| gptkbp:significance |
inhibition causes cholinergic crisis
|
| gptkbp:structure |
serine hydrolase
|
| gptkbp:substrate |
gptkb:acetylcholine
|
| gptkbp:usedIn |
nerve agent antidote research
|
| gptkbp:bfsParent |
gptkb:ACHE_gene
|
| gptkbp:bfsLayer |
8
|