Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
class of drugs
|
| gptkbp:approvedBy |
gptkb:FDA
gptkb:EMA |
| gptkbp:cause |
gptkb:center
gptkb:depression behavioral changes confusion tolerance anxiety withdrawal hallucinations agitation sleepwalking dependence falls in elderly paradoxical reactions accidental injury abnormal thinking impaired driving ability next-day impairment rebound insomnia |
| gptkbp:contraindication |
severe liver impairment
|
| gptkbp:developedBy |
alternatives to benzodiazepines
|
| gptkbp:duration |
short to intermediate
|
| https://www.w3.org/2000/01/rdf-schema#label |
Z-drugs
|
| gptkbp:includes |
gptkb:zopiclone
gptkb:zolpidem gptkb:zaleplon |
| gptkbp:introducedIn |
1990s
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:marketedAs |
non-benzodiazepine hypnotics
|
| gptkbp:mechanismOfAction |
GABA-A receptor agonist
|
| gptkbp:metabolism |
liver
|
| gptkbp:notRecommendedFor |
long-term use
|
| gptkbp:regulates |
controlled substance in many countries
|
| gptkbp:riskFactor |
dependence
withdrawal symptoms complex sleep behaviors |
| gptkbp:shouldBeTaken |
immediately before bedtime
|
| gptkbp:shouldBeUsedWithCautionIn |
elderly
patients with history of substance abuse patients with respiratory impairment |
| gptkbp:shouldNotBeCombinedWith |
gptkb:beer
gptkb:CNS_depressants |
| gptkbp:shouldNotBeTakenWith |
heavy or high-fat meals
|
| gptkbp:sideEffect |
dizziness
headache drowsiness memory impairment |
| gptkbp:usedFor |
treatment of insomnia
|
| gptkbp:bfsParent |
gptkb:Nonbenzodiazepine_hypnotics
|
| gptkbp:bfsLayer |
6
|