|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
BIG-3
SWD3 homolog
WD repeat protein 5
|
|
gptkbp:associatedWith
|
histone H3 lysine 4 methylation
|
|
gptkbp:binds
|
MLL1 WIN motif
histone H3 tail
|
|
gptkbp:domain
|
gptkb:WD40_repeat
|
|
gptkbp:encodedBy
|
WDR5 gene
|
|
gptkbp:Entrez_Gene_ID
|
11091
ENSG00000164951
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
WD repeat-containing protein 5
|
|
gptkbp:function
|
regulation of gene expression
component of histone methyltransferase complexes
|
|
gptkbp:gene
|
gptkb:WDR5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
WDR5
|
|
gptkbp:interactsWith
|
gptkb:ASH2L
gptkb:DPY30
gptkb:RBBP5
gptkb:MLL1
|
|
gptkbp:involves
|
leukemia
cancer progression
|
|
gptkbp:length
|
334 amino acids
|
|
gptkbp:locatedOnChromosome
|
9q34.2
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:OMIM
|
606495
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Drosophila_melanogaster
|
|
gptkbp:participatedIn
|
COMPASS complex
SET1/MLL complexes
|
|
gptkbp:PDB
|
2GNQ
2H14
3EMH
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:RefSeq
|
NM_017588
|
|
gptkbp:requires
|
transcriptional activation
H3K4 methylation
|
|
gptkbp:role
|
embryonic development
stem cell maintenance
oncogenesis
|
|
gptkbp:structure
|
seven-bladed beta-propeller
|
|
gptkbp:target
|
small molecule inhibitors
|
|
gptkbp:UniProtID
|
P61964
|
|
gptkbp:bfsParent
|
gptkb:KMT2D
gptkb:ARD_Infonacht
|
|
gptkbp:bfsLayer
|
7
|