Ubiquitin-Proteasome System

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:biological_pathway gptkb:protein_degradation_system
gptkbp:alternativeName	gptkb:UPS
gptkbp:component	gptkb:proteasome ubiquitin E1 enzyme E2 enzyme E3 ligase
gptkbp:discoveredBy	gptkb:Aaron_Ciechanover gptkb:Avram_Hershko gptkb:Irwin_Rose
gptkbp:dysregulationAssociatedWith	gptkb:Alzheimer's_disease gptkb:Parkinson's_disease gptkb:cancer neurodegenerative diseases
gptkbp:foundIn	eukaryotic cells
gptkbp:function	protein degradation protein quality control regulation of cellular processes
gptkbp:involvedIn	signal transduction protein turnover transcriptional regulation antigen processing removal of misfolded proteins removal of damaged proteins
gptkbp:NobelPrizeYear	2004 Chemistry discovery of ubiquitin-mediated protein degradation
gptkbp:processor	ubiquitination proteolysis
gptkbp:proteasomeIs	large protease complex
gptkbp:proteasomeLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:regulates	gptkb:immune_response apoptosis DNA repair cell cycle
gptkbp:target	gptkb:bortezomib proteasome inhibitors
gptkbp:ubiquitinationLeadsTo	protein degradation
gptkbp:ubiquitinationRequires	gptkb:ATP
gptkbp:ubiquitinChainType	monoubiquitin multiubiquitin chain polyubiquitin chain
gptkbp:ubiquitinIs	small regulatory protein
gptkbp:ubiquitinLinkage	Lys48-linked Lys63-linked
gptkbp:bfsParent	gptkb:D010141
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Ubiquitin-Proteasome System