Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
protein degradation system |
| gptkbp:alternativeName |
gptkb:UPS
|
| gptkbp:component |
gptkb:proteasome
ubiquitin E1 enzyme E2 enzyme E3 ligase |
| gptkbp:discoveredBy |
gptkb:Aaron_Ciechanover
gptkb:Avram_Hershko gptkb:Irwin_Rose |
| gptkbp:dysregulationAssociatedWith |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:cancer neurodegenerative diseases |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
protein degradation
protein quality control regulation of cellular processes |
| https://www.w3.org/2000/01/rdf-schema#label |
Ubiquitin-Proteasome System
|
| gptkbp:involvedIn |
signal transduction
protein turnover transcriptional regulation antigen processing removal of misfolded proteins removal of damaged proteins |
| gptkbp:NobelPrizeYear |
2004
Chemistry discovery of ubiquitin-mediated protein degradation |
| gptkbp:processor |
ubiquitination
proteolysis |
| gptkbp:proteasomeIs |
large protease complex
|
| gptkbp:proteasomeLocation |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:regulates |
apoptosis
DNA repair immune response cell cycle |
| gptkbp:target |
gptkb:bortezomib
proteasome inhibitors |
| gptkbp:ubiquitinationLeadsTo |
protein degradation
|
| gptkbp:ubiquitinationRequires |
gptkb:ATP
|
| gptkbp:ubiquitinChainType |
monoubiquitin
multiubiquitin chain polyubiquitin chain |
| gptkbp:ubiquitinIs |
small regulatory protein
|
| gptkbp:ubiquitinLinkage |
Lys48-linked
Lys63-linked |
| gptkbp:bfsParent |
gptkb:D010141
|
| gptkbp:bfsLayer |
7
|