Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
UDP-glucuronosyltransferase 2B7
UDPGT 2B7 UGT2B7_HUMAN |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:liver_disease adverse drug reaction adverse drug reactions opioid toxicity variation in drug response |
| gptkbp:discoveredBy |
Mackenzie et al.
|
| gptkbp:encodes |
UDP-glucuronosyltransferase 2B7
|
| gptkbp:Entrez_Gene_ID |
7364
|
| gptkbp:enzymeCommissionNumber |
2.4.1.17
|
| gptkbp:expressedIn |
gptkb:kidney
liver intestine |
| gptkbp:fullName |
UDP glucuronosyltransferase family 2 member B7
|
| gptkbp:function |
catalyzes glucuronidation of drugs, xenobiotics, and endogenous compounds
|
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasPolymorphism |
UGT2B7*2 (H268Y)
|
| gptkbp:hasTranscriptVariant |
2
|
| gptkbp:HGNC_ID |
12556
|
| https://www.w3.org/2000/01/rdf-schema#label |
UGT2B7
|
| gptkbp:involvedIn |
drug metabolism
steroid metabolism bilirubin metabolism morphine metabolism |
| gptkbp:length |
529 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_4
4q13.2 |
| gptkbp:molecularWeight |
60 kDa
|
| gptkbp:OMIM |
601068
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Ugt2b
Ugt2b1 |
| gptkbp:pathway |
drug metabolism - cytochrome P450
Phase II conjugation glucuronidation pathway |
| gptkbp:proteinFamily |
UDP-glucuronosyltransferase family
|
| gptkbp:referenceGenome |
gptkb:GRCh38
|
| gptkbp:substrate |
gptkb:codeine
gptkb:morphine gptkb:valproic_acid gptkb:oxazepam nonsteroidal anti-inflammatory drugs estriol bilirubin |
| gptkbp:UniProtID |
P16662
|
| gptkbp:bfsParent |
gptkb:ertugliflozin
|
| gptkbp:bfsLayer |
6
|