|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
UDP-glucuronosyltransferase 2B7
UDPGT 2B7
UGT2B7_HUMAN
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:liver_disease
gptkb:adverse_drug_reaction
adverse drug reactions
opioid toxicity
variation in drug response
|
|
gptkbp:discoveredBy
|
Mackenzie et al.
|
|
gptkbp:encodes
|
UDP-glucuronosyltransferase 2B7
|
|
gptkbp:Entrez_Gene_ID
|
7364
|
|
gptkbp:enzymeCommissionNumber
|
2.4.1.17
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
|
|
gptkbp:fullName
|
UDP glucuronosyltransferase family 2 member B7
|
|
gptkbp:function
|
catalyzes glucuronidation of drugs, xenobiotics, and endogenous compounds
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
UGT2B7*2 (H268Y)
|
|
gptkbp:hasTranscriptVariant
|
2
|
|
gptkbp:HGNC_ID
|
12556
|
|
gptkbp:involvedIn
|
drug metabolism
steroid metabolism
bilirubin metabolism
morphine metabolism
|
|
gptkbp:length
|
529 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q13.2
|
|
gptkbp:molecularWeight
|
60 kDa
|
|
gptkbp:OMIM
|
601068
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ugt2b
Ugt2b1
|
|
gptkbp:pathway
|
drug metabolism - cytochrome P450
Phase II conjugation
glucuronidation pathway
|
|
gptkbp:proteinFamily
|
UDP-glucuronosyltransferase family
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:substrate
|
gptkb:codeine
gptkb:morphine
gptkb:valproic_acid
gptkb:oxazepam
nonsteroidal anti-inflammatory drugs
estriol
bilirubin
|
|
gptkbp:UniProtID
|
P16662
|
|
gptkbp:bfsParent
|
gptkb:chromosome_4q13-q21
gptkb:ertugliflozin
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
UGT2B7
|