Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gene therapy
|
| gptkbp:amendedBy |
CD52 gene knockout
TRAC gene knockout |
| gptkbp:antigen |
gptkb:CD19
|
| gptkbp:cellType |
allogeneic T cells
|
| gptkbp:clinicalTrialPhase |
Phase 1
|
| gptkbp:cookingMethod |
off-the-shelf
|
| gptkbp:countryOfOrigin |
gptkb:France
gptkb:United_States |
| gptkbp:developedBy |
gptkb:Servier
gptkb:Cellectis gptkb:Allogene_Therapeutics |
| gptkbp:firstClinicalUse |
2015
|
| gptkbp:geneEditingTechnology |
gptkb:TALEN
|
| https://www.w3.org/2000/01/rdf-schema#label |
UCART19
|
| gptkbp:indication |
leukemia
B-cell malignancies |
| gptkbp:mechanismOfAction |
redirects T cells to kill CD19+ cells
|
| gptkbp:notableCase |
gptkb:CALM_trial
gptkb:PALL_trial |
| gptkbp:regulates |
investigational
|
| gptkbp:routeOfAdministration |
intravenous
|
| gptkbp:bfsParent |
gptkb:Cellectis
|
| gptkbp:bfsLayer |
7
|