Tryptophan oxygenase

GPTKB entity

Statements (23)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:tryptophan_2,3-dioxygenase
gptkbp:associatedWith hypertryptophanemia
gptkbp:catalyzes oxidation of L-tryptophan to N-formylkynurenine
gptkbp:cofactor hemoglobin
gptkbp:discoveredBy 1950s
gptkbp:EC_number 1.13.11.11
gptkbp:enzymeClassification oxidoreductase
gptkbp:foundIn liver
gptkbp:gene gptkb:TDO2
https://www.w3.org/2000/01/rdf-schema#label Tryptophan oxygenase
gptkbp:inhibitedBy tryptophan analogs
gptkbp:organism gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:pathway tryptophan catabolism
gptkbp:product N-formylkynurenine
gptkbp:regulates induced by glucocorticoids
inhibited by heme deficiency
gptkbp:requires molecular oxygen
gptkbp:structure homotetramer
gptkbp:substrate L-tryptophan
gptkbp:bfsParent gptkb:TDO2
gptkbp:bfsLayer 7