Statements (23)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:enzyme
|
gptkbp:alternativeName |
gptkb:tryptophan_2,3-dioxygenase
|
gptkbp:associatedWith |
hypertryptophanemia
|
gptkbp:catalyzes |
oxidation of L-tryptophan to N-formylkynurenine
|
gptkbp:cofactor |
hemoglobin
|
gptkbp:discoveredBy |
1950s
|
gptkbp:EC_number |
1.13.11.11
|
gptkbp:enzymeClassification |
oxidoreductase
|
gptkbp:foundIn |
liver
|
gptkbp:gene |
gptkb:TDO2
|
https://www.w3.org/2000/01/rdf-schema#label |
Tryptophan oxygenase
|
gptkbp:inhibitedBy |
tryptophan analogs
|
gptkbp:organism |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
gptkbp:pathway |
tryptophan catabolism
|
gptkbp:product |
N-formylkynurenine
|
gptkbp:regulates |
induced by glucocorticoids
inhibited by heme deficiency |
gptkbp:requires |
molecular oxygen
|
gptkbp:structure |
homotetramer
|
gptkbp:substrate |
L-tryptophan
|
gptkbp:bfsParent |
gptkb:TDO2
|
gptkbp:bfsLayer |
7
|