Triose-phosphate isomerase

URI: https://gptkb.org/entity/Triose-phosphate_isomerase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activeSiteResidue Glu165 (human)
His95 (human)
gptkbp:associatedWith gptkb:anemia
gptkbp:catalyzes interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
gptkbp:cofactor none
gptkbp:deficiencyCauses gptkb:triosephosphate_isomerase_deficiency
gptkbp:discoveredBy gptkb:Carl_Neuberg
gptkbp:EC_number 5.3.1.1
gptkbp:enzymeClassification gptkb:isomerase
gptkbp:foldable gptkb:TIM_barrel
gptkbp:foundIn gptkb:gluconeogenesis_pathway
gptkb:glycolysis_pathway
gptkbp:gene gptkb:TPI1
gptkbp:GO_term gptkb:GO:0004807
https://www.w3.org/2000/01/rdf-schema#label Triose-phosphate isomerase
gptkbp:inhibitedBy phosphoenolpyruvate
gptkbp:locatedIn gptkb:cytoplasm
gptkbp:molecularWeight ~27 kDa
gptkbp:OMIM 190450
gptkbp:PDB gptkb:1TIM
gptkbp:presentIn gptkb:Bacteria
archaea
eukaryotes
gptkbp:product gptkb:glyceraldehyde_3-phosphate
dihydroxyacetone phosphate
gptkbp:requires energy production
gptkbp:structure homodimer
gptkbp:substrate gptkb:glyceraldehyde_3-phosphate
dihydroxyacetone phosphate
gptkbp:UniProtID gptkb:P60174
gptkbp:bfsParent gptkb:P60174
gptkbp:bfsLayer 8