|
gptkbp:instanceOf
|
gptkb:cell_membrane
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD71
TFRC
|
|
gptkbp:antibodyTarget
|
CD71 antibody
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:anemia
gptkb:hemochromatosis
|
|
gptkbp:binds
|
gptkb:transferrin
|
|
gptkbp:biologicalProcess
|
receptor-mediated endocytosis
iron ion homeostasis
transferrin receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
Ian M. Trowbridge
|
|
gptkbp:discoveredIn
|
1981
|
|
gptkbp:encodedBy
|
TFRC gene
|
|
gptkbp:Entrez_Gene_ID
|
7037
ENSG00000072274
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
gptkb:placenta
gptkb:testis
gptkb:thymus
brain
liver
lymph nodes
spleen
bone marrow
endothelial cells
tumor cells
epithelial cells
erythroid precursors
proliferating cells
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
iron uptake
|
|
gptkbp:glycosylation
|
N-linked
|
|
gptkbp:HGNC_ID
|
11740
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Transferrin receptor 1
|
|
gptkbp:internalization
|
clathrin-mediated endocytosis
|
|
gptkbp:locatedOnChromosome
|
gptkb:3q29
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~95 kDa
|
|
gptkbp:OMIM
|
190010
|
|
gptkbp:PDB
|
1CX8
|
|
gptkbp:significance
|
target for cancer therapy
marker for cell proliferation
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:UniProtID
|
P02786
|
|
gptkbp:bfsParent
|
gptkb:Transferrin
|
|
gptkbp:bfsLayer
|
7
|