Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:discoveredIn |
1976
|
| gptkbp:EC_number |
5.99.1.3
|
| gptkbp:foundIn |
eukaryotic cells
some prokaryotes |
| gptkbp:fullName |
DNA topoisomerase II
|
| gptkbp:function |
alters DNA topology
introduces transient double-strand breaks in DNA relieves DNA supercoiling untangles DNA during replication and transcription |
| gptkbp:gene |
TOP2A
TOP2B |
| gptkbp:hasIsoform |
Topo II alpha
Topo II beta |
| https://www.w3.org/2000/01/rdf-schema#label |
Topo II
|
| gptkbp:inhibitedBy |
gptkb:doxorubicin
gptkb:mitoxantrone antineoplastic agent teniposide |
| gptkbp:relatedTo |
gptkb:DNA_gyrase
Topo I |
| gptkbp:requires |
gptkb:ATP
|
| gptkbp:role |
DNA repair
transcription DNA replication chromosome segregation |
| gptkbp:target |
antibiotics
anticancer drugs |
| gptkbp:bfsParent |
gptkb:Topo
|
| gptkbp:bfsLayer |
7
|