Thyroid transcription factor 1

URI: https://gptkb.org/entity/Thyroid_transcription_factor_1
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:alsoKnownAs gptkb:NKX2-1
gptkb:TTF-1
gptkbp:associatedWith gptkb:cancer
gptkb:brain-lung-thyroid_syndrome
congenital hypothyroidism
gptkbp:discoveredIn 1990s
gptkbp:encodedBy NKX2-1 gene
gptkbp:Entrez_Gene_ID 7080
gptkbp:expressedIn gptkb:cancer
thyroid gland
forebrain
gptkbp:familyMember gptkb:NK2_homeobox_family
gptkbp:foundIn humans
mice
gptkbp:function regulates transcription of genes involved in development
regulates expression of surfactant proteins
regulates expression of thyroglobulin
gptkbp:hasDNABindingDomain homeodomain
https://www.w3.org/2000/01/rdf-schema#label Thyroid transcription factor 1
gptkbp:locatedOnChromosome 14q13.3
gptkbp:molecularWeight ~38 kDa
gptkbp:OMIM 600635
gptkbp:regulates SFTPB gene
SFTPC gene
thyroperoxidase gene
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P43699
gptkbp:usedAsMarkerIn lung adenocarcinoma diagnosis
thyroid carcinoma diagnosis
gptkbp:bfsParent gptkb:NKX2-1
gptkbp:bfsLayer 7