|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abnormalForm
|
neurofibrillary tangles
|
|
gptkbp:aggregatesFrom
|
forms paired helical filaments
|
|
gptkbp:aggregationLeadsTo
|
neurofibrillary tangles
|
|
gptkbp:alternativeName
|
gptkb:MAPT
gptkb:microtubule-associated_protein_tau
|
|
gptkbp:alternativeSplicing
|
six isoforms in adult human brain
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:tauopathies
frontotemporal dementia
|
|
gptkbp:degradedBy
|
autophagy
ubiquitin-proteasome system
|
|
gptkbp:dephosphorylationBy
|
gptkb:protein_phosphatase_2A
|
|
gptkbp:discoveredBy
|
gptkb:Marc_Kirschner
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:MAPT_gene
|
|
gptkbp:foundIn
|
gptkb:human
neurons
|
|
gptkbp:function
|
stabilizes microtubules
|
|
gptkbp:hasBiomarker
|
neurodegenerative diseases
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tau protein
|
|
gptkbp:interactsWith
|
microtubules
protein kinases
protein phosphatases
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
cell signaling
neurodegeneration
microtubule assembly
microtubule stabilization
neuronal polarity
axon outgrowth
memory impairment (in disease)
|
|
gptkbp:locale
|
axons
cell body (in disease)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17q21
|
|
gptkbp:molecularWeight
|
45-65 kDa
|
|
gptkbp:mutationAssociatedWith
|
causes frontotemporal dementia with parkinsonism
|
|
gptkbp:pathologicalRole
|
impairs neuronal function when aggregated
|
|
gptkbp:phosphorylates
|
serine
threonine
|
|
gptkbp:phosphorylationLeadsTo
|
reduced microtubule binding
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:presentIn
|
cerebrospinal fluid (increased in disease)
glial cells (in disease)
|
|
gptkbp:structure
|
contains microtubule-binding repeats
|
|
gptkbp:studiedIn
|
gptkb:transgenic_mouse_models
|
|
gptkbp:target
|
therapeutic research in Alzheimer's disease
|
|
gptkbp:UniProtID
|
P10636
|
|
gptkbp:bfsParent
|
gptkb:Microtubule_Associated_Protein
|
|
gptkbp:bfsLayer
|
6
|