|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:Rac1
|
|
gptkbp:alias
|
T-lymphoma invasion and metastasis-inducing protein 1
KIAA2016
TIAM
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
neurodevelopmental disorders
cancer metastasis
|
|
gptkbp:biologicalProcess
|
signal transduction
regulation of actin cytoskeleton organization
Rho guanyl-nucleotide exchange factor activity
|
|
gptkbp:cellularComponent
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:encodes
|
gptkb:T-cell_lymphoma_invasion_and_metastasis-inducing_protein_1
|
|
gptkbp:Entrez_Gene_ID
|
7074
ENSG00000156299
|
|
gptkbp:expressedIn
|
brain
epithelial tissues
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
guanine nucleotide exchange factor (GEF)
|
|
gptkbp:Homo_sapiens_ortholog
|
gptkb:TIAM1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIAM1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:Rac1
Par3
|
|
gptkbp:involvedIn
|
cell migration
neuronal development
cell adhesion
|
|
gptkbp:length
|
1591 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 21
|
|
gptkbp:mutationAssociatedWith
|
gptkb:autism_spectrum_disorder
intellectual disability
cancer progression
|
|
gptkbp:OMIM
|
601661
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:proteinFamily
|
gptkb:Ras-binding_domain
gptkb:PH_domain
coiled-coil domain
DH domain
PDZ domain
|
|
gptkbp:regulates
|
gptkb:synaptic_plasticity
neurite outgrowth
cell polarity
cell-cell junctions
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q13009
|
|
gptkbp:bfsParent
|
gptkb:Tiam1
gptkb:human_chromosome_21
|
|
gptkbp:bfsLayer
|
7
|