TGF-beta signaling superfamily
GPTKB entity
Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:alsoKnownAs |
Transforming Growth Factor-beta superfamily
|
| gptkbp:database |
Gene Ontology: GO:0007179
Pfam: PF00019 (TGF-beta domain) UniProt: P01137 (TGF-beta1) Reactome: R-HSA-170834 (TGF-beta receptor signaling) |
| gptkbp:discoveredBy |
multiple researchers
|
| gptkbp:example |
gptkb:GDF5
gptkb:Activin_A gptkb:BMP2 gptkb:Nodal gptkb:TGF-beta1 |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
gptkb:metazoans
|
| gptkbp:function |
cell differentiation
embryonic development immune system regulation cell growth regulation apoptosis regulation |
| gptkbp:GO_term |
GO:0007179 (transforming growth factor beta receptor signaling pathway)
|
| https://www.w3.org/2000/01/rdf-schema#label |
TGF-beta signaling superfamily
|
| gptkbp:includes |
Activin family
BMP family GDF family Nodal family TGF-beta family |
| gptkbp:ligand |
cytokine
|
| gptkbp:mechanismOfAction |
transcriptional regulation
phosphorylation cascade ligand-receptor binding |
| gptkbp:memberOf |
cytokine superfamily
|
| gptkbp:mutationAssociatedWith |
gptkb:Loeys-Dietz_syndrome
gptkb:hereditary_hemorrhagic_telangiectasia gptkb:Marfan_syndrome |
| gptkbp:recipient |
serine/threonine kinase receptors
|
| gptkbp:regulates |
immune cell function
extracellular matrix production stem cell fate |
| gptkbp:relatedTo |
gptkb:cancer
gptkb:cardiovascular_disease developmental disorders fibrosis |
| gptkbp:subfamily |
Activin subfamily
BMP subfamily GDF subfamily TGF-beta subfamily |
| gptkbp:type |
gptkb:SMAD_proteins
|
| gptkbp:bfsParent |
gptkb:BMP_signaling_pathway
|
| gptkbp:bfsLayer |
7
|